The timelines for developing vaccines against infectious diseases are lengthy, and often
vaccines that reach the stage of large phase 3 field trials fail to provide the desired level of …

Background Plasmodium parasites undergo several major developmental transitions during
their complex lifecycle, which are enabled by precisely ordered gene expression programs …

Research on Plasmodium parasites has driven breakthroughs in reducing malaria morbidity
and mortality. Experimental analysis of in vivo/ex vivo versus in vitro samples serve unique …

Malaria is spread by the transmission of sexual stage parasites, called gametocytes.
However, with Plasmodium falciparum, gametocytes can only be detected in peripheral …

The pathogenesis of severe Plasmodium falciparum malaria involves cytoadhesive
microvascular sequestration of infected erythrocytes, mediated by P. falciparum erythrocyte …

Plasmodium knowlesi, a model malaria parasite, is responsible for a significant portion of
zoonotic malaria cases in Southeast Asia and must be controlled to avoid disease severity …

Clonally variant genes (CVGs) play fundamental roles in the adaptation of Plasmodium
falciparum to fluctuating conditions of the human host. However, their expression patterns …

Single-nucleotide variations (SNVs) in RNA, arising from co-and post-transcriptional
phenomena including transcription errors and RNA-editing, are well studied in a range of …

Background Sequencing technology advancements opened new opportunities to use
transcriptomics for studying malaria pathology and epidemiology. Even though in recent …

The development of vaccines against sea lice in salmon farming is complex, expensive, and
takes several years for commercial availability. Recently, transcriptome studies in sea louse …