The human innate and adaptive immune systems consist of effector cells producing
cytokines (interleukins, interferons, chemokines, and numerous other mediators). Usually, a …

Background Sepsis and septic shock remain drivers for mortality in critically ill patients. The
heterogeneity of the syndrome hinders the generation of reproducible numbers on mortality …

As of 2017, the World Health Organization has made the recognition, prevention, and
management of sepsis a global health priority. 1 Hippocrates considered the term a …

Management of the patient with sepsis comprises three key branches: control of the
underlying infection, haemodynamic stabilization, and modulation of the host response …

Sepsis is a life-threatening condition and a global disease burden. Today, the
heterogeneous syndrome is defined as severe organ dysfunction caused by a dysregulated …

Early management of sepsis and septic shock is crucial for patients' prognosis. As the
Emergency Department (ED) is the place where the first medical contact for septic patients is …

Therapeutic drug monitoring (TDM) of beta-lactam antibiotics is recommended to address
the variability in exposure observed in critical illness. However, the impact of TDM-guided …

Purpose To evaluate the effects of early combination therapy with intravenous vitamin C and
thiamine on recovery from organ failure in patients with septic shock. Methods The ascorbic …

Background Sepsis, a life-threatening organ dysfunction induced by infection, is a major
public health problem. This study aimed to evaluate the frequency and mortality of sepsis …

OBJECTIVES: To determine the association of catecholamine dose, lactate concentration,
and timing from shock onset at vasopressin initiation with in-hospital mortality. DESIGN …