In the area of drug development and clinical pharmacotherapy, a profound understanding of
the pharmacokinetics and potential adverse reactions associated with the drug under …

Previously in this Journal, we reported that severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) spike (S) blocked sorting nexin 27 (SNX27)-mediated endocytic recycling of …

Sudden cardiac death (SCD) is an unpredictable and common mode of death in patients
with heart failure (HF). Alterations in calcium handling may lead to malignant arrhythmias …

Background and aims Heart failure (HF) is often triggered by hypertension and can benefit
from antihypertensive treatment. We aimed to investigate whether pulse pressure (PP) could …

Purpose This study examined the effects of plasma renin activity (PRA), angiotensin II (Ang
II) and aldosterone (PAC) concentrations as well as common polymorphisms in the β1 …

ABSTRACT Introduction: Cytochrome P450 (CYP) is a monooxygenase superfamily
mediating the elimination of anti-hypertensive drugs. Polymorphisms of CYP would lead to …

Pharmacogenomic (PGx) information can guide drug and dose selection, optimize therapy
outcomes, and/or decrease the risk of adverse drug events (ADEs). This report demonstrates …

Resistant hypertension (RHTN) prevalence ranges from 4 to 19% in Africa. There is a
paucity of data on the role of genetic variation on RHTN among Africans. We set out to …

Beta blockers (BBs) have important side effects that contribute to low adherence and
persistence. Therefore, the optimal choice of BB is an important mode to prevent BB's side …

Cardiovascular medicine witnessed notable advances for the past decade. Multiomics
research offers a new lens for precision/personalized medicine for existing and emerging …