Background The possibility to better predict the severity of the disease in a patient newly
diagnosed with multiple sclerosis would allow the treatment strategy to be personalized and …

Introduction: Intrathecal B-lymphocyte activation is a hallmark of multiple sclerosis (MS), a
multi-factorial inflammatory-demyelinating disease of the central nervous system. Such …

The identity of target antigen (s) in multiple sclerosis (MS) remains elusive despite much
effort to identify it. We analyzed cerebrospinal fluid (CSF) from patients with MS, other …

The intrathecal synthesis of IgM, determined at clinical onset in patients with multiple
sclerosis, was found to correlate with the degree of disability (as evaluated by means of the …

Antibodies and oxidative stress are hallmarks of multiple sclerosis (MS) lesions. We aimed
to clarify the relation between them, their role in MS patients and to investigate their …

Background The ability to predict the future progression of MS represents a key issue for the
neurologist. The aim of the study was to create a multifactorial prognostic index (MPI) …

Multiple sclerosis is an inflammatory demyelinating disease of the central nervous system
with no clear etiology. Until recently, most studies have emphasized the role of T cells in the …

Multiple sclerosis (MS), the most important human inflammatory demyelinating disease of
the central nervous system, is characterized by various clinical disease courses …

A characteristic feature of the CNS inflammatory response in multiple sclerosis (MS) is the
intrathecal synthesis of IgG and the presence of oligoclonal bands. A strong correlation …

Multiple sclerosis is a highly complex and heterogeneous disease. At the onset it often
presents as a clinically isolated syndrome. Thereafter relapses are followed by periods of …