The presence of intrathecal IgM synthesis (ITMS) has been associated with an aggressive
multiple sclerosis (MS) clinical course. In the present systematic review, we aimed at …

Abstract Background Oligoclonal IgM (OCMB) and IgG (OCGB) bands were found to be
associated with poor multiple sclerosis (MS) prognosis. Objective We aimed to evaluate the …

Multiple sclerosis (MS) is a demyelinating and neurodegenerative disease of the central
nervous system. It affects young people, and a considerable percentage of patients need the …

We prospectively assessed the risk of second relapse in 192 patients with clinically isolated
syndromes (CIS) divided into three groups: patients lacking oligoclonal IgG bands (OC-IgG …

Background: There is increasing evidence on cerebrospinal fluid (CSF) oligoclonal IgM
(OCIgM) predicting a more aggressive disease course in relapsing–remitting Multiple …

Increasing evidence has suggested that both antibody-dependent and antibody-
independent functions of B cells are involved in multiple sclerosis (MS). The contrasting …

Oligoclonal IgG bands (OCGB) are characteristic of multiple sclerosis (MS). Most patients
show OCGB exclusively in cerebrospinal fluid (CSF). Others have serum bands with …

The detection of intrathecal IgA synthesis (IAS) in multiple sclerosis (MS) could be
underestimated. To assess it, we develop a highly sensitive assay based on isoelectric …

We described previously that multiple sclerosis (MS) patients with oligoclonal IgM against
myelin lipids (M+) develop an aggressive disease. Our aim was to assess possible …

Multiple sclerosis (MS), the most important human inflammatory demyelinating disease of
the central nervous system, is characterized by heterogenous genetic backgrounds and …