Multiple sclerosis (MS) is the most common disabling neurological disease in young adults
and is thought to result from an autoimmune attack against autoantigens within the myelin …

Multiple sclerosis is a highly complex and heterogeneous disease. At the onset it often
presents as a clinically isolated syndrome. Thereafter relapses are followed by periods of …

Background B cells and humoral immune responses play an important role in the
pathogenesis and diagnosis of multiple sclerosis (MS). A characteristic finding in patients …

The objective of this study was to investigate whether the presence of lipid-specific
oligoclonal IgM bands (LS-OCMB) in cerebrospinal fluid (CSF) influences the response to …

Clinicians treating multiple sclerosis (MS) patients need biomarkers in order to predict an
individualized prognosis for every patient, that is, characteristics that can be measured in an …

Background: Intrathecal IgM synthesis is reported to be associated with a worse prognosis in
adults with multiple sclerosis (MS). Objective: To study the predictive value of intrathecal IgM …

Background Intrathecal immunoglobulin M (IgM) synthesis has been demonstrated in the
early disease stages of multiple sclerosis (MS) as a predictor factor of a worsening disease …

Background: There is emerging evidence that intrathecal IgM synthesis (ITMS) is a risk factor
for conversion to clinically defined multiple sclerosis (CDMS) in clinically isolated syndrome …

Background The presence of oligoclonal IgM bands (OCMB) in cerebrospinal fluid (CSF) is
an unfavourable prognostic marker in multiple sclerosis. There is no commercial test to …

Background: Multiple sclerosis (MS) is the most common demyelinating disease and
characterized by immunological changes. Oligoclonal bands of IgG in CSF not seen in …