Multiple sclerosis (MS) is the most common human inflammatory, demyelinating and
degenerative disorder of the CNS. Based mostly on work in experimental autoimmune …

Currently, there is no single test for multiple sclerosis (MS). Diagnosis is confirmed through
clinical evaluation, abnormalities revealed by magnetic resonance imaging (MRI), and …

Background: Recent findings have shown a correlation between the intrathecal IgG index
and variants at the immunoglobulin heavy chain (IGHC) locus in patients with multiple …

Multiple sclerosis (MS) is characterized by the intrathecal synthesis (ITS) of
immunoglobulins (Igs), which, although nonspecific, is the strongest biological marker. Since …

Multiple sclerosis impairment is mainly driven by the progressive phase, whose pathology
remains elusive. No drug has yet been able to halt this phase so therapeutic management …

IgA antibodies do not activate complement and may compete with and protect against
myelin degradation caused by IgM and IgG in multiple sclerosis (MS). We retrospectively …

Multiple sclerosis (MS) is an inflammatory demyelinating disease of the central nervous
system. Although most studies have emphasized the role of T cells in the pathogenesis of …

Objectives: It was the aim of this study to evaluate if the quantitative intrathecal
immunoglobulin G (IgG) synthesis correlates with the brain atrophy and the total lesion …

Introducción La mayoría de los pacientes con esclerosis múltiple (EM) debutan con un
síndrome clínico aislado (SCA). Es importante diferenciar este SCA de otras patologías …

Antibodies and oxidative stress are hallmarks of multiple sclerosis (MS) lesions. We aimed
to clarify the relation between them, their role in MS patients and to investigate their …