Background and Aims Starting biologic treatment early in the course of inflammatory bowel
disease (IBD) may be associated with higher efficacy, especially in Crohn's disease (CD) …

Recent studies have identified mucosal healing on endoscopy as a key prognostic
parameter in the management of inflammatory bowel diseases (IBD), thus highlighting the …

The management of inflammatory bowel disease represents a key component of clinical
practice for members of the British Society of Gastroenterology (BSG). There has been …

Background Endoscopic mucosal healing is an established treatment target for UC, yet the
value of achieving histological remission remains unclear. Aims To evaluate histological …

Background Biologics are used for the treatment of rheumatoid arthritis and many other
conditions. While the efficacy of biologics has been established, there is uncertainty …

Background Nonresponse and loss of response to anti‐TNF therapies in Crohn's disease
represent significant clinical problems for which clear management guidelines are lacking …

Crohn's disease is a relapsing systemic inflammatory disease, mainly affecting the
gastrointestinal tract with extraintestinal manifestations and associated immune disorders …

The occurrence of strictures as a complication of Crohn's disease is a significant clinical
problem. No specific antifibrotic therapies are available. This systematic review …

Anti-tumour necrosis factor (TNF) antibodies have been widely used for approximately 25
years now. The first clinical observations in patients with refractory Crohn's disease rapidly …

BACKGROUND AND AIMS: We sought to assess the evolution of Crohn's disease behavior
in an American population-based cohort. METHODS: Medical records of all Olmsted County …