[HTML][HTML] Application of AOPs to assist regulatory assessment of chemical risks–Case studies, needs and recommendations
L Bajard, O Adamovsky, K Audouze, K Baken… - Environmental …, 2023 - Elsevier
While human regulatory risk assessment (RA) still largely relies on animal studies, new
approach methodologies (NAMs) based on in vitro, in silico or non-mammalian alternative …
approach methodologies (NAMs) based on in vitro, in silico or non-mammalian alternative …
[HTML][HTML] Anogenital distance as a toxicological or clinical marker for fetal androgen action and risk for reproductive disorders
CL Schwartz, S Christiansen, AM Vinggaard… - Archives of …, 2019 - Springer
Male reproductive development is intricately dependent on fetal androgen action.
Consequently, disrupted androgen action during fetal life can interfere with the development …
Consequently, disrupted androgen action during fetal life can interfere with the development …
[HTML][HTML] Developmental toxicity of Nafion byproduct 2 (NBP2) in the Sprague-Dawley rat with comparisons to hexafluoropropylene oxide-dimer acid (HFPO-DA or …
JM Conley, CS Lambright, N Evans… - Environment …, 2022 - Elsevier
Abstract Nafion byproduct 2 (NBP2) is a polyfluoroalkyl ether sulfonic acid that was recently
detected in surface water, drinking water, and human serum samples from monitoring …
detected in surface water, drinking water, and human serum samples from monitoring …
Androgens and the masculinization programming window: human–rodent differences
RM Sharpe - Biochemical Society Transactions, 2020 - portlandpress.com
Human male reproductive disorders are common and may have a fetal origin—the testicular
dysgenesis syndrome (TDS) hypothesis. In rats, experimentally induced TDS disorders …
dysgenesis syndrome (TDS) hypothesis. In rats, experimentally induced TDS disorders …
[HTML][HTML] Cumulative maternal and neonatal effects of combined exposure to a mixture of perfluorooctanoic acid (PFOA) and perfluorooctane sulfonic acid (PFOS) …
JM Conley, CS Lambright, N Evans… - Environment …, 2022 - Elsevier
Globally, biomonitoring data demonstrate virtually all humans carry residues of multiple per-
and polyfluoroalkyl substances (PFAS). Despite pervasive co-exposure, limited mixtures …
and polyfluoroalkyl substances (PFAS). Despite pervasive co-exposure, limited mixtures …
Application of a framework for grouping and mixtures toxicity assessment of PFAS: A closer examination of dose-additivity approaches
Environmental occurrence and biomonitoring data for per-and polyfluoroalkyl substances
(PFAS) demonstrate that humans are exposed to mixtures of PFAS. This article presents a …
(PFAS) demonstrate that humans are exposed to mixtures of PFAS. This article presents a …
[HTML][HTML] Phthalate metabolites in urine of children and adolescents in Germany. Human biomonitoring results of the German Environmental Survey GerES V, 2014 …
G Schwedler, E Rucic, R Lange, A Conrad… - International journal of …, 2020 - Elsevier
During the population representative German Environmental Survey of Children and
Adolescents (GerES V, 2014–2017) 2256 first-morning void urine samples from 3 to 17 …
Adolescents (GerES V, 2014–2017) 2256 first-morning void urine samples from 3 to 17 …
[HTML][HTML] A mixture of 15 phthalates and pesticides below individual chemical no observed adverse effect levels (NOAELs) produces reproductive tract malformations in …
JM Conley, CS Lambright, N Evans, M Cardon… - Environment …, 2021 - Elsevier
Humans carry residues of multiple synthetic chemicals at any given point in time. Research
has demonstrated that compounds with varying molecular initiating events (MIE) that disrupt …
has demonstrated that compounds with varying molecular initiating events (MIE) that disrupt …
[HTML][HTML] Cumulative risk assessment of five phthalates in European children and adolescents
R Lange, N Vogel, P Schmidt, A Gerofke… - International Journal of …, 2022 - Elsevier
Abstract The European Human Biomonitoring Initiative (HBM4EU) assessed human
biomonitoring data on phthalates in children and adolescents, that were sampled between …
biomonitoring data on phthalates in children and adolescents, that were sampled between …
[HTML][HTML] Mechanisms of testicular disruption from exposure to bisphenol A and phtalates
Great attention has been paid in recent years to the harmful effects of various chemicals that
interfere with our natural hormone balance, collectively known as endocrine-disrupting …
interfere with our natural hormone balance, collectively known as endocrine-disrupting …