As a strategy to improve the therapeutic success of chimeric antigen receptor T cells (CART)
directed against solid tumors, we here test the combinatorial use of CART and IMSA101, a …

Sporadic inclusion body myositis (sIBM) is the most common muscle disease of older people
and is clinically characterized by slowly progressive asymmetrical muscle weakness …

The NLRP3 inflammasome is pivotal in orchestrating the immune response induced by
nanoparticle adjuvants. Understanding the intricate mechanisms underlying the activation of …

Inflammasomes comprise a group of protein complexes with fundamental roles in the
induction of inflammation. Upon sensing stress factors, their assembly induces the activation …

Atherosclerosis, a complex metabolic-immune disease characterized by chronic
inflammation driven by the buildup of lipid-rich plaques within arterial walls, has emerged as …

Background Pyroptosis, an inflammatory form of programmed cell death, has been
implicated in the pathogenesis and progression of several cancers. However, the …

This investigation explores the combined influence of SCD Probiotics and
tauroursodeoxycholic acid (TUDCA) on liver health in elderly male Sprague-Dawley rats …

The inflammasome regulates the innate inflammatory response and is involved in
autoimmune diseases. In this study, we explored the levels of IL-18 and IL-1β in serum and …

The emergence of combination antiretroviral therapy (cART) has greatly transformed the life
expectancy of people living with HIV (PWH). Today, over 76% of the individuals with HIV …

Background To determine the effect of colchicine on cancer risk in patients with the immune-
mediated inflammatory diseases (IMIDs)-related to colchicine use. Methods This is a time …