Background and Purpose—The purpose of these guidelines is to provide an up-to-date
comprehensive set of recommendations in a single document for clinicians caring for adult …

The presence of a patent foramen ovale (PFO) is implicated in the pathogenesis of a number
of medical conditions; however, the subject remains controversial and no official statements …

This is the fourth edition of the UK National clinical guideline for stroke. It is an integral part
of the broader goal of the Intercollegiate Stroke Working Party to improve the care of people …

Objectives We aimed to assess whether limiting the inclusion criteria solely to English-
language publications affected the overall conclusions of evidence syntheses. Study Design …

Background We conducted a systematic review and meta‐analysis of randomized controlled
trials (RCT s) comparing patent foramen ovale (PFO) closure, anticoagulation, and …

About one-fourth of ischemic strokes occur in working-aged individuals in the high-income
countries, with worldwide increasing incidence in this age group from 1980s to present …

Options for the secondary prevention of stroke in patients younger than 60 years who have
had a cryp‑togenic ischaemic stroke thought to be secondary to patent foramen ovale (PFO) …

Objective To assess the effects of abbreviated literature searches on evidence syntheses
conclusions. Study design and setting We randomly selected 60 Cochrane reviews of …

Background: Pulmonary embolism (PE) is associated with increased risk for ischemic stroke,
but the underlying mechanism remains unclear. The authors hypothesized that paradoxical …

Objective To examine the relative impact of three management options in patients aged< 60
years with cryptogenic stroke and a patent foramen ovale (PFO): PFO closure plus …