The increasing prevalence of older adults with diabetes has become a major social burden.
Diabetes, frailty, and cognitive dysfunction are closely related to the mechanisms of aging …

Adult-onset autoimmune (AOA) diabetes pathophysiology starts with immune changes,
followed by dysglycaemia and overt disease. AOA diabetes can occur as classic type 1 …

Background As the disease progresses, many patients with type 2 diabetes have difficulty in
reaching treatment goals. We aimed to assess the efficacy and safety of tirzepatide, a novel …

Eight years have passed since the publication of the only guideline on cardiac rehabilitation
(CR) in Japan,“Guidelines for rehabilitation in patients with cardiovascular disease (JCS …

Background Due to potential ethnic differences in the pathophysiology of type 2 diabetes,
new therapeutics need to be evaluated in Japanese patients. We aimed to assess the safety …

Aging is considered to be accelerated by insulin signaling in lower organisms, but it
remained unclear whether this could hold true for mammals. Here we show that mice with …

In Japan, a super-aged society, deaths from atherosclerotic cardiovascular disease
(ASCVD), especially cardiac diseases including coronary artery disease (CAD) such as …

We sought to verify the reliability of machine learning (ML) in developing diabetes prediction
models by utilizing big data. To this end, we compared the reliability of gradient boosting …

Aims To evaluate the efficacy and safety of imeglimin for up to 52 weeks as combination
therapy with insulin in Japanese patients with type 2 diabetes. Materials and Methods This …

Aim Use of sodium‐glucose co‐transporter‐2 inhibitors (SGLT2is) for glycaemic control is
increasing in individuals with type 2 diabetes (T2D) for their additional benefits on heart …