Trauma can affect any individual at any location and at any time over a lifespan. The
disruption of macrobarriers and microbarriers induces instant activation of innate immunity …

Uncontrolled haemorrhage is a major preventable cause of death in patients with traumatic
injury. Trauma-induced coagulopathy (TIC) describes abnormal coagulation processes that …

Importance Optimal transfusion strategies in traumatic hemorrhage are unknown. Reports
suggest a beneficial effect of 4-factor prothrombin complex concentrate (4F-PCC) on blood …

Importance The association between total prehospital time and mortality in physician-staffed
trauma systems remains uncertain. Objective To describe the association of total prehospital …

BACKGROUND Historically, hemorrhage has been attributed as the leading cause (40%) of
early death. However, a rigorous, real-time classification of the cause of death (COD) has …

Objective: To address the clinical and regulatory challenges of optimal primary endpoints for
bleeding patients by developing consensus-based recommendations for primary clinical …

BACKGROUND Hemorrhage is the most common cause of potentially preventable trauma
deaths, but no studies have focused on all civilian traumatic deaths from hemorrhage, so we …

Transfusing platelets during massive hemorrhage is debated because of a lack of high-
quality evidence concerning outcomes in trauma patients. The objective of this study was to …

Background Tourniquet use has been proven to reduce mortality on the battlefield. Although
empirically transitioned to the civilian environment, data substantiating survival benefit …

Objective: To establish a trauma preventable/potentially preventable death rate (PPPDR)
within a heavily populated county in Texas. Summary: The National Academies of Sciences …