A bidirectional relationship exists between hypertension and psychiatric disorders, including
unipolar and bipolar depression, anxiety, post-traumatic stress disorder (PTSD), psychosis …

The brain is arguably the most fascinating and complex organ in the human body.
Recreating the brain in vitro is an ambition restricted by our limited understanding of its …

Intrathecal pseudodelivery of drugs is a novel route to administer medications to treat
neurodegenerative diseases based on the CSF-sink therapeutic strategy by means of …

Introduction Successful neuropharmacology requires optimization of CNS drug delivery and,
by extension, free drug concentrations at brain molecular targets. Detailed assessment of …

Chronic inflammation plays an important role in the development of neurodegenerative
diseases, such as Parkinson's disease (PD). In the present study, we synthesized 25 novel …

The pharmaceutical research sector has been facing the challenge of neurotherapeutics
development and its inherited high-risk and high-failure-rate nature for decades. This hurdle …

Background Pediatric brain tumors (PBT) stand as the leading cause of cancer‐related
deaths in children. Chemoradiation protocols have improved survival rates, even for non …

Gliomas are the most common primary brain tumors in adults. A diffuse infiltrative growth
pattern and high resistance to therapy make them largely incurable, but there are significant …

Neurological disorders pose a huge worldwide challenge to the healthcare system,
necessitating innovative strategies for targeted drug delivery to the central nervous system …

Alzheimer's disease (AD) is a progressive neurodegenerative disease that disrupts cognitive
function and severely affects the quality of life. Existing drugs only improve cognitive function …