Pancreatic cancer (pancreatic ductal adenocarcinoma (PDAC/PC)) has been an aggressive
disease that is associated with early metastases. It is characterized by dense and …

Purpose: We hypothesized that autophagy inhibition would increase response to
chemotherapy in the preoperative setting for patients with pancreatic adenocarcinoma. We …

Pancreatic fibrosis is caused by the excessive deposits of extracellular matrix (ECM) and
collagen fibers during repeated necrosis to repair damaged pancreatic tissue. Pancreatic …

Background Dysregulated expression and activation of receptor tyrosine kinases (RTKs) are
associated with a range of human cancers. However, current RTK-targeting strategies exert …

Recently, fibroblast growth factors are identified to play a vital role in the development and
progression of human pancreatic cancer. FGF pathway is critical involved in numerous …

Background Although the pancreatic ductal adenocarcinoma (PDAC) presents high mortality
and metastatic potential, there is a lack of effective therapies and a low survival rate for this …

Background. Pancreatic cancer is one of most aggressive malignancies with a dismal
prognosis. Activation of PI3K/AKT signaling is instrumental in pancreatic cancer …

The tumor microenvironment (TME) plays a key role in promoting and sustaining cancer
growth. Adipose tissue (AT), due to its anatomical distribution, is a prevalent component of …

Objective: Pancreatic cancer is a highly lethal malignancy globally. This study aimed to
probe and validate immune-related prognostic mRNAs as therapeutic targets for pancreatic …

Pancreatic cancer (PC) is very deadly and difficult to treat. The presence of hypoxia has
been shown to increase the probability of cancer developing and spreading. Pancreatic …