Targeting growth factor signaling pathways in pancreatic cancer: towards inhibiting chemoresistance

N Xelwa, GP Candy, J Devar… - Frontiers in …, 2021 - frontiersin.org
Pancreatic cancer is one of the most deadly cancers, ranking amongst the top leading cause
of cancer related deaths in developed countries. Features such as dense stroma …

Integrated analysis identifies a pathway-related competing endogenous RNA network in the progression of pancreatic cancer

F Zu, P Liu, H Wang, T Zhu, J Sun, W Sheng, X Tan - BMC cancer, 2020 - Springer
Background It is well acknowledged that cancer-related pathways play pivotal roles in the
progression of pancreatic cancer (PC). Employing Integrated analysis, we aim to identify the …

[HTML][HTML] The prognostic value of HGF-c-MET signaling pathway in Gastric Cancer: a study based on TCGA and GEO databases

C Wang, W Xi, J Ji, Q Cai, Q Zhao, J Jiang… - … Journal of Medical …, 2020 - ncbi.nlm.nih.gov
Gastric cancer is a heterogeneous tumor that underlying molecular mechanisms are largely
unclear. This study aimed to elucidate the expression level of HGF-c-MET in gastric cancer …

Clustering analysis and prognostic model based on PI3K/AKT-related genes in pancreatic cancer

X Deng, X He, Z Yang, J Huang, L Zhao, M Wen… - Frontiers in …, 2023 - frontiersin.org
Background Pancreatic cancer is one of most aggressive malignancies with a dismal
prognosis. Activation of PI3K/AKT signaling is instrumental in pancreatic cancer …

HGF/c-MET: A Potential Target for the Treatment of Various Cancers

K Anitha, K Dua, DK Chellappan… - Current Enzyme …, 2023 - ingentaconnect.com
Background: Cancer is the abnormal growth of cells in the body due to an imbalance in the
normal apoptotic pathways. The abnormality in the cancer cells makes them malignant …

Molecular Characterization and Therapeutic Opportunities in KRAS Wildtype Pancreatic Ductal Adenocarcinoma

A Desai, AH Xiao, D Choi, MD Toruner, D Walden… - Cancers, 2024 - mdpi.com
Simple Summary Pancreatic cancer is predicted to be the second-highest cause of cancer
mortality in the US by 2040. It is driven by various mutations including KRAS, TP53, SMAD4 …

CircRNAs in Pancreatic Cancer: New Tools for Target Identification and Therapeutic Intervention

UH Weidle, A Nopora - Cancer Genomics & Proteomics, 2024 - cgp.iiarjournals.org
We have reviewed the literature for circular RNAs (circRNAs) with efficacy in preclinical
pancreatic-cancer related in vivo models. The identified circRNAs target chemoresistance …

Aberrant RON and MET co-overexpression as novel prognostic biomarkers of shortened patient survival and therapeutic targets of tyrosine kinase inhibitors in …

CY Hu, XM Xu, B Hong, ZG Wu, Y Qian… - Frontiers in …, 2019 - frontiersin.org
RON (recepteur d'origine nantais) and MET (hepatocyte growth factor receptor) are tyrosine
kinase receptors. Various cancers have aberrant RON and MET expression and activation …

Identification of immune-and oxidative stress-related signature genes as potential targets for mRNA vaccines for pancreatic cancer patients

J Li, Y Han, N Zhao, L Lv, P Ma, Y Zhang, M Li, H Sun… - Medicine, 2024 - journals.lww.com
Adenocarcinoma of the pancreas (PAAD) is one of the deadliest malignant tumors, and
messenger ribonucleic acid vaccines, which constitute the latest generation of vaccine …

Construction and validation of an immune-based prognostic model for pancreatic adenocarcinoma based on public databases

M Mao, H Ling, Y Lin, Y Chen, B Xu, R Zheng - Frontiers in Genetics, 2021 - frontiersin.org
Background Pancreatic adenocarcinoma (PAAD) is a highly lethal and aggressive tumor
with poor prognoses. The predictive capability of immune-related genes (IRGs) in PAAD has …