Precocious puberty in children is one of the common endocrine diseases in paediatrics.
Epidemiological surveys have shown that the number of children with precocious puberty …

Central precocious puberty (CPP) is a condition in which the hypothalamus–pituitary–
gonadal system is activated earlier than the normal developmental stage. The etiology …

Context Loss-of-function mutations in the maternally imprinted genes, MKRN3 and DLK1,
are associated with central precocious puberty (CPP). Mutations in MKRN3 are the most …

Puberty is a critical process characterized by several physical and psychological changes
that culminate in the achievement of sexual maturation and fertility. The onset of puberty …

Context Idiopathic central precocious puberty (iCPP) is defined by the premature
reactivation of the hypothalamic-pituitary-gonadal axis with normal magnetic resonance …

Growth and pubertal development are complex and interconnected processes, disruption of
which leads to abnormal development of the adult height or secondary sexual …