Intra-articular drug delivery has a number of advantages over systemic administration;
however, for the past 20 years, intra-articular treatment options for the management of knee …

Osteoarthritis (OA) has long been viewed as a degenerative disease of cartilage, but
accumulating evidence indicates that inflammation has a critical role in its pathogenesis …

Metabolism is important for cartilage and synovial joint function. Under adverse
microenvironmental conditions, mammalian cells undergo a switch in cell metabolism from a …

Purpose Low back pain (LBP) is the most disabling condition worldwide. Although LBP
relates to different spinal pathologies, vertebral bone marrow lesions visualized as Modic …

Cell death with morphological and molecular features of apoptosis has been detected in
osteoarthritic (OA) cartilage, which suggests a key role for chondrocyte death/survival in the …

Osteoarthritis (OA), the commonest arthritis, is characterized by the progressive destruction
of cartilage, leading to disability. The Current early clinical treatment strategy for OA often …

Although osteoarthritis (OA) has existed since the dawn of humanity, its pathogenesis
remains poorly understood. OA is no longer considered a “wear and tear” condition but …

During the osteoarthritis (OA) process, activation of immune systems, whether innate or
adaptive, is strongly associated with low-grade systemic inflammation. This process is …

Senescent cells (SnCs) are associated with age-related pathologies. Osteoarthritis is a
chronic disease characterized by pain, loss of cartilage, and joint inflammation, and its …

Osteoarthritis (OA) is the most common cause of disability in worldwide population, which is
characterized by cartilage breakdown, synovial fibrosis, osteophyte formation and pain …