Targeting chronic innate inflammatory pathways, the main road to prevention of osteoarthritis progression

G Herrero-Beaumont, S Perez-Baos… - Biochemical …, 2019 - Elsevier
Osteoarthritis (OA) is a chronic joint disease characterized by cartilage degradation,
osteophyte formation, subchondral bone sclerosis, and synovitis. Systemic factors such as …

Pathophysiological landscape of osteoarthritis

P Kulkarni, A Martson, R Vidya, S Chitnavis… - Advances in clinical …, 2021 - Elsevier
A sharp rise in osteoarthritis (OA) incidence is expected as over 25% of world population
ages in the coming decade. Although OA is considered a degenerative disease, mounting …

Identification of cartilage microbial DNA signatures and associations with knee and hip osteoarthritis

CM Dunn, C Velasco, A Rivas… - Arthritis & …, 2020 - Wiley Online Library
Objective Alterations of the gut microbiota have been implicated in many forms of arthritis,
but an examination of cartilage microbial patterns has not been performed. This study was …

Phenotype diversity of macrophages in osteoarthritis: implications for development of macrophage modulating therapies

NV Mushenkova, NG Nikiforov… - International Journal of …, 2022 - mdpi.com
Chronic inflammation is implicated in numerous human pathologies. In particular, low-grade
inflammation is currently recognized as an important mechanism of osteoarthritis (OA), at …

[HTML][HTML] Inflammation and intracellular metabolism: new targets in OA

R Liu-Bryan - Osteoarthritis and Cartilage, 2015 - Elsevier
Articular cartilage degeneration is hallmark of osteoarthritis (OA). Low-grade chronic
inflammation in the joint can promote OA progression. Emerging evidence indicates that …

Exosomes in intercellular communication and implications for osteoarthritis

S Asghar, GJ Litherland, JC Lockhart… - …, 2020 - academic.oup.com
Osteoarthritis (OA) is the most prevalent of the musculoskeletal conditions and represents a
significant public health burden. While degeneration of articular cartilage is a key feature, it …

Damage-associated molecular patterns in the pathogenesis of osteoarthritis: potentially novel therapeutic targets

JH Rosenberg, V Rai, MF Dilisio… - Molecular and cellular …, 2017 - Springer
Osteoarthritis (OA) is a chronic disease that degrades the joints and is often associated with
increasing age and obesity. The two most common sites of OA in adults are the knee and hip …

Clinical outcomes of knee osteoarthritis treated with an autologous protein solution injection: a 1-year pilot double-blinded randomized controlled trial

E Kon, L Engebretsen, P Verdonk… - … American journal of …, 2018 - journals.sagepub.com
Background: Osteoarthritis (OA) is a debilitating disease resulting in substantial pain and
functional limitations. A novel blood derivative has been developed to concentrate both …

Leukocyte-rich platelet-rich plasma injections do not up-modulate intra-articular pro-inflammatory cytokines in the osteoarthritic knee

E Mariani, V Canella, L Cattini, E Kon, M Marcacci… - PloS one, 2016 - journals.plos.org
Introduction The presence of leukocytes in platelet concentrates is deemed to cause
deleterious effects when injected intra articularly. The aim of this study is to analyse both …

Immunoengineering biomaterials for musculoskeletal tissue repair across lifespan

J Han, AN Rindone, JH Elisseeff - Advanced Materials, 2024 - Wiley Online Library
Musculoskeletal diseases and injuries are among the leading causes of pain and morbidity
worldwide. Broad efforts have focused on developing pro‐regenerative biomaterials to treat …