[HTML][HTML] Defensins: a double-edged sword in host immunity

D Xu, W Lu - Frontiers in immunology, 2020 - frontiersin.org
Defensins are a major family of host defense peptides expressed predominantly in
neutrophils and epithelial cells. Their broad antimicrobial activities and multifaceted …

A new antibiotic kills pathogens without detectable resistance

LL Ling, T Schneider, AJ Peoples, AL Spoering… - Nature, 2015 - nature.com
Antibiotic resistance is spreading faster than the introduction of new compounds into clinical
practice, causing a public health crisis. Most antibiotics were produced by screening soil …

[HTML][HTML] Reassessing the host defense peptide landscape

EF Haney, SK Straus, REW Hancock - Frontiers in chemistry, 2019 - frontiersin.org
Current research has demonstrated that small cationic amphipathic peptides have strong
potential not only as antimicrobials, but also as antibiofilm agents, immune modulators, and …

Intracellular targeting mechanisms by antimicrobial peptides

CF Le, CM Fang, SD Sekaran - Antimicrobial agents and …, 2017 - Am Soc Microbiol
Antimicrobial peptides (AMPs) are expressed in various living organisms as first-line host
defenses against potential harmful encounters in their surroundings. AMPs are short …

Antimicrobial peptides (AMPs): Ancient compounds that represent novel weapons in the fight against bacteria

JM Ageitos, A Sánchez-Pérez, P Calo-Mata… - Biochemical …, 2017 - Elsevier
Antimicrobial peptides (AMPs) are short peptidic molecules produced by most living
creatures. They help unicellular organisms to successfully compete for nutrients with other …

Host defense peptide mimicking antimicrobial amino acid polymers and beyond: design, synthesis and biomedical applications

Y Wu, K Chen, J Wang, M Chen, Y Chen, Y She… - Progress in Polymer …, 2023 - Elsevier
Microbial infections endanger human health and life. Conventional antibiotics has saved
countless human lives, however, is seriously challenged by the quick emergence of …

Defensins: The natural peptide antibiotic

X Gao, J Ding, C Liao, J Xu, X Liu, W Lu - Advanced drug delivery reviews, 2021 - Elsevier
Defensins are a family of cationic antimicrobial peptides active against a broad range of
infectious microbes including bacteria, viruses and fungi, playing important roles as innate …

Essential oils in food preservation: mode of action, synergies, and interactions with food matrix components

M Hyldgaard, T Mygind, RL Meyer - Frontiers in microbiology, 2012 - frontiersin.org
Essential oils are aromatic and volatile liquids extracted from plants. The chemicals in
essential oils are secondary metabolites, which play an important role in plant defense as …

Designing antimicrobial peptides: form follows function

CD Fjell, JA Hiss, REW Hancock… - Nature reviews Drug …, 2012 - nature.com
Multidrug-resistant bacteria are a severe threat to public health. Conventional antibiotics are
becoming increasingly ineffective as a result of resistance, and it is imperative to find new …

The vast structural diversity of antimicrobial peptides

J Koehbach, DJ Craik - Trends in Pharmacological Sciences, 2019 - cell.com
Antimicrobial peptides (AMPs) occur in all kingdoms of life and are integral to host defense.
They have diverse structures and target a variety of organisms, both by nonspecific …