[HTML][HTML] Defensins: a double-edged sword in host immunity
D Xu, W Lu - Frontiers in immunology, 2020 - frontiersin.org
Defensins are a major family of host defense peptides expressed predominantly in
neutrophils and epithelial cells. Their broad antimicrobial activities and multifaceted …
neutrophils and epithelial cells. Their broad antimicrobial activities and multifaceted …
A new antibiotic kills pathogens without detectable resistance
LL Ling, T Schneider, AJ Peoples, AL Spoering… - Nature, 2015 - nature.com
Antibiotic resistance is spreading faster than the introduction of new compounds into clinical
practice, causing a public health crisis. Most antibiotics were produced by screening soil …
practice, causing a public health crisis. Most antibiotics were produced by screening soil …
[HTML][HTML] Reassessing the host defense peptide landscape
Current research has demonstrated that small cationic amphipathic peptides have strong
potential not only as antimicrobials, but also as antibiofilm agents, immune modulators, and …
potential not only as antimicrobials, but also as antibiofilm agents, immune modulators, and …
Intracellular targeting mechanisms by antimicrobial peptides
Antimicrobial peptides (AMPs) are expressed in various living organisms as first-line host
defenses against potential harmful encounters in their surroundings. AMPs are short …
defenses against potential harmful encounters in their surroundings. AMPs are short …
Antimicrobial peptides (AMPs): Ancient compounds that represent novel weapons in the fight against bacteria
JM Ageitos, A Sánchez-Pérez, P Calo-Mata… - Biochemical …, 2017 - Elsevier
Antimicrobial peptides (AMPs) are short peptidic molecules produced by most living
creatures. They help unicellular organisms to successfully compete for nutrients with other …
creatures. They help unicellular organisms to successfully compete for nutrients with other …
Host defense peptide mimicking antimicrobial amino acid polymers and beyond: design, synthesis and biomedical applications
Y Wu, K Chen, J Wang, M Chen, Y Chen, Y She… - Progress in Polymer …, 2023 - Elsevier
Microbial infections endanger human health and life. Conventional antibiotics has saved
countless human lives, however, is seriously challenged by the quick emergence of …
countless human lives, however, is seriously challenged by the quick emergence of …
Defensins: The natural peptide antibiotic
Defensins are a family of cationic antimicrobial peptides active against a broad range of
infectious microbes including bacteria, viruses and fungi, playing important roles as innate …
infectious microbes including bacteria, viruses and fungi, playing important roles as innate …
Essential oils in food preservation: mode of action, synergies, and interactions with food matrix components
Essential oils are aromatic and volatile liquids extracted from plants. The chemicals in
essential oils are secondary metabolites, which play an important role in plant defense as …
essential oils are secondary metabolites, which play an important role in plant defense as …
Designing antimicrobial peptides: form follows function
CD Fjell, JA Hiss, REW Hancock… - Nature reviews Drug …, 2012 - nature.com
Multidrug-resistant bacteria are a severe threat to public health. Conventional antibiotics are
becoming increasingly ineffective as a result of resistance, and it is imperative to find new …
becoming increasingly ineffective as a result of resistance, and it is imperative to find new …
The vast structural diversity of antimicrobial peptides
J Koehbach, DJ Craik - Trends in Pharmacological Sciences, 2019 - cell.com
Antimicrobial peptides (AMPs) occur in all kingdoms of life and are integral to host defense.
They have diverse structures and target a variety of organisms, both by nonspecific …
They have diverse structures and target a variety of organisms, both by nonspecific …