For more than 50 years dequalinium chloride has been used successfully as an antiseptic
drug and disinfectant, particularly for clinical purposes. Given the success of dequalinium …

Antimicrobial peptides (AMPs) are a large class of innate immunity effectors with a
remarkable capacity to inactivate microorganisms. Their ability to kill bacteria by …

The natural antibiotic teixobactin kills pathogenic bacteria without detectable resistance. The
difficult synthesis and unfavourable solubility of teixobactin require modifications, yet …

The peptidoglycan biosynthetic pathway is a critical process in the bacterial cell and is
exploited as a target for the design of antibiotics. This pathway culminates in the production …

Insects can assemble defensive microbiomes on their body surfaces to defend against
fungal parasitic infections. The strategies employed by fungal pathogens to combat host …

Microbes typically secrete a plethora of molecules to promote niche colonization. Soil-
dwelling microbes are well-known producers of antimicrobials that are exploited to …

As a family of cationic host defense peptides, defensins are mainly synthesized by Paneth
cells, neutrophils, and epithelial cells, contributing to host defense. Their biological functions …

Antimicrobial peptides (AMPs) have been proposed as a novel class of antimicrobials that
could aid the fight against antibiotic resistant bacteria. The mode of action of AMPs as acting …

Antimicrobial peptides (AMPs) are ribosomally synthesized natural antibiotics that are
crucial effectors of innate immune systems in all living organisms. AMPs are diverse …

The pulmonary airways are continuously exposed to bacteria. As a first line of defense
against infection, the airway surface liquid (ASL) contains a complex mixture of antimicrobial …