The emergence of infections caused by multi-drug resistant (MDR) pathogens pose a major
burden to modern healthcare. Exacerbating this issue is the substantial decline in …

This review summarizes ongoing research aimed at finding novel drugs as alternatives to
traditional antibiotics. Anti-virulence approaches, phage therapy and therapeutic antibodies …

Resistance to antibiotics is one of the main current threats to human health and every year
multi-drug resistant bacteria are infecting millions of people worldwide, with many dying as a …

Antimicrobial peptides (AMPs) are evolutionarily ancient molecules that act as the key
components in the invertebrate innate immunity against invading pathogens. Several AMPs …

Fungi and bacteria compete with an arsenal of secreted molecules for their ecological niche.
This repertoire represents a rich and inexhaustible source for antibiotics and fungicides …

Since the discovery of magainins, cecropins and defensins 30 years ago, antimicrobial
peptides (AMPs) have been hailed as a potential solution to the dearth of novel antibiotic …

Cationic antimicrobial peptides (CAPs) such as defensins are ubiquitously found innate
immune molecules that often exhibit broad activity against microbial pathogens and …

Defensins are small basic amphiphilic peptides (up to 5 kDa) that have been shown to be
important effector molecules of the innate immune system of animals, plants and fungi. In …

We present the performance of HADDOCK, our information-driven docking software, in the
second edition of the D3R Grand Challenge. In this blind experiment, participants were …

Endogenous host defense peptides (HDPs) are among the most ancient immune mediators,
constituting a first line of defense against invading pathogens across the evolutionary …