Mechanisms underlying HIV-associated cognitive impairment and emerging therapies for its management
People living with HIV are affected by the chronic consequences of neurocognitive
impairment (NCI) despite antiretroviral therapies that suppress viral replication, improve …
impairment (NCI) despite antiretroviral therapies that suppress viral replication, improve …
[HTML][HTML] Covid-19 interface with drug misuse and substance use disorders
IE Cisneros, KA Cunningham - Neuropharmacology, 2021 - Elsevier
Abstract The coronavirus disease 2019 (Covid-19) pandemic intensified the already
catastrophic drug overdose and substance use disorder (SUD) epidemic, signaling a …
catastrophic drug overdose and substance use disorder (SUD) epidemic, signaling a …
Presence of Tat and transactivation response element in spinal fluid despite antiretroviral therapy
Objective: The aim of this study was to measure the protein concentration and biological
activity of HIV-1 Tat in cerebrospinal fluid (CSF) of individuals on suppressive antiretroviral …
activity of HIV-1 Tat in cerebrospinal fluid (CSF) of individuals on suppressive antiretroviral …
The synthetic opioid fentanyl increases HIV replication and chemokine co-receptor expression in vitro
The US is experiencing a major public health crisis that is fueled by the illicit use of synthetic
opioids including fentanyl. While several drugs of abuse can enhance viral replication …
opioids including fentanyl. While several drugs of abuse can enhance viral replication …
Role of inflammasomes in HIV-1 and drug abuse mediated neuroinflammaging
Despite the effectiveness of combined antiretroviral therapy (cART) in suppressing virus
replication, chronic inflammation remains one of the cardinal features intersecting HIV-1 …
replication, chronic inflammation remains one of the cardinal features intersecting HIV-1 …
Crossroads of drug abuse and HIV infection: neurotoxicity and CNS reservoir
Drug abuse is a common comorbidity in people infected with HIV. HIV-infected individuals
who abuse drugs are a key population who frequently experience suboptimal outcomes …
who abuse drugs are a key population who frequently experience suboptimal outcomes …
Cocaine sensitizes the CD4+ T cells for HIV infection by co-stimulating NFAT and AP-1
AL Sharma, D Shaffer, D Netting, M Tyagi - Iscience, 2022 - cell.com
The productive infection of HIV, which generates new viral progeny, depends on the
activation status of the cell. In this study, we found cocaine exposure sensitizes partially …
activation status of the cell. In this study, we found cocaine exposure sensitizes partially …
Human immunodeficiency virus type-1 (HIV-1) transcriptional regulation, latency and therapy in the central nervous system
The central nervous system (CNS) is highly compartmentalized and serves as a specific site
of human immunodeficiency virus (HIV) infection. Therefore, an understanding of the cellular …
of human immunodeficiency virus (HIV) infection. Therefore, an understanding of the cellular …
[HTML][HTML] Effects of drug and hazardous alcohol use on having a detectable HIV viral load: An adherence mediation analysis
ER Cachay, TS Moges, H Qin, L Bamford… - Addictive Behaviors …, 2023 - Elsevier
Objectives People living with HIV (PWH) with substance or alcohol use often have
unsuppressed plasma HIV viral loads (pVL). The degree to which substance and alcohol …
unsuppressed plasma HIV viral loads (pVL). The degree to which substance and alcohol …
[HTML][HTML] HIV and Drug Use: A Tale of Synergy in Pulmonary Vascular Disease Development
CM Cook, VD Craddock, AK Ram… - Comprehensive …, 2023 - ncbi.nlm.nih.gov
Over the past two decades, with the advent and adoption of highly active anti-retroviral
therapy, HIV-1 infection, a once fatal and acute illness, has transformed into a chronic …
therapy, HIV-1 infection, a once fatal and acute illness, has transformed into a chronic …