The effects of intrathecal clonidine alone and prior to intrathecal morphine were studied on
electrically evoked Aβ and C fibre activity in the dorsal horn of the halothane-anaesthetised …

Alpha2-adrenergic agonists given intrathecally result in antinociception and
intracerebroventricularly (ICV) in sedation. To examine whether different alpha2-adrenergic …

This article reviews evidence that hyperpolarization-activated, cation nonselective (HCN)
channels, the molecular basis of the Ih current, potentially represent valid targets for novel …

ABSTRACT ABBREVIATIONS: CGRP, calcitonin gene-related peptide; CLON, clonidine;
DMET, dexmedetomidine; DMSO, dimethyl sulfoxide; JME, just maximally effective; ST-91, 2 …

Intrathecal administration of alpha adrenoceptor agonists in rats produces a significant
elevation of nociceptive thresholds as measured by hot-plate and tail-flick latencies. That …

In this study, we examined whether activation of 5-HT1A receptors elicits antinociception in
response to acute noxious chemical, thermal and mechanical stimuli in mice. In the writhing …

The effects of detomidine, a veterinary sedative analgesic, were studied in the horse. Novel
objective techniques were employed to assess the analgesic and sedative potency of this …

3.2. Tachykinin antagonists 3.3. Association of long duration synaptic excitation and C fibre
primary afferent input 3.4. Excitatory amino acid as C fibre transmitters 3.5. Capsaicin as a …

Dexmedetomidine (DEX) may have some therapeutic advantages over the racemate
medetomidine (MED). Here we have examined how serum concentrations of DEX correlate …

Flupirtine is a novel, centrally acting, non-opioid analgesic agent. The present investigation
was undertaken to ascertain which neuronal systems might be responsible for its …