Epigenetics and human disease: translating basic biology into clinical applications
D Rodenhiser, M Mann - Cmaj, 2006 - Can Med Assoc
Epigenetics refers to the study of heritable changes in gene expression that occur without a
change in DNA sequence. Research has shown that epigenetic mechanisms provide an" …
change in DNA sequence. Research has shown that epigenetic mechanisms provide an" …
The impact of metabolism on DNA methylation
CL Ulrey, L Liu, LG Andrews… - Human molecular …, 2005 - academic.oup.com
Methylation of genomic cytosines is one of the best characterized epigenetic mechanisms,
and investigation of its relationship with other biochemical pathways represents a critical …
and investigation of its relationship with other biochemical pathways represents a critical …
Epigenetics in prostate cancer: biologic and clinical relevance
C Jerónimo, PJ Bastian, A Bjartell, GM Carbone… - European urology, 2011 - Elsevier
CONTEXT: Prostate cancer (PCa) is one of the most common human malignancies and
arises through genetic and epigenetic alterations. Epigenetic modifications include DNA …
arises through genetic and epigenetic alterations. Epigenetic modifications include DNA …
Activation of DNA Methyltransferase 1 by EBV LMP1 Involves c-Jun NH2-Terminal Kinase Signaling
CL Tsai, HP Li, YJ Lu, C Hsueh, Y Liang, CL Chen… - Cancer research, 2006 - AACR
EBV latent membrane protein 1 (LMP1) activates cellular DNA methyltransferases, resulting
in hypermethylation and silencing of E-cadherin. However, the underlying mechanism …
in hypermethylation and silencing of E-cadherin. However, the underlying mechanism …
EZH2, an epigenetic driver of prostate cancer
YA Yang, J Yu - Protein & cell, 2013 - academic.oup.com
The histone methyltransferase EZH2 has been in the limelight of the field of cancer
epigenetics for a decade now since it was first discovered to exhibit an elevated expression …
epigenetics for a decade now since it was first discovered to exhibit an elevated expression …
Tumor Suppressor Gene Inactivation during Cadmium-Induced Malignant Transformation of Human Prostate Cells Correlates with Overexpression of de Novo DNA …
L Benbrahim-Tallaa, RA Waterland… - Environmental …, 2007 - ehp.niehs.nih.gov
Background Aberrant DNA methylation is common in carcinogenesis. The typical pattern
appears to involve reduced expression of maintenance DNA methyltransferase, DNMT1 …
appears to involve reduced expression of maintenance DNA methyltransferase, DNMT1 …
Posttranslational Protein Modification in Archaea
J Eichler, MWW Adams - Microbiology and Molecular Biology …, 2005 - Am Soc Microbiol
One of the first hurdles to be negotiated in the postgenomic era involves the description of
the entire protein content of the cell, the proteome. Such efforts are presently complicated by …
the entire protein content of the cell, the proteome. Such efforts are presently complicated by …
Global methylation profiling for risk prediction of prostate cancer
Purpose: The aim of this study was to investigate the promoter hypermethylation as
diagnostic markers to detect malignant prostate cells and as prognostic markers to predict …
diagnostic markers to detect malignant prostate cells and as prognostic markers to predict …
PDLIM4 repression by hypermethylation as a potential biomarker for prostate cancer.
DK Vanaja, KV Ballman, BW Morlan, JC Cheville… - Clinical cancer research …, 2006 - AACR
PURPOSE: We analyzed the expression of genes to identify reliable molecular markers in
the diagnosis and progression of prostate cancer. EXPERIMENTAL DESIGN: Gene …
the diagnosis and progression of prostate cancer. EXPERIMENTAL DESIGN: Gene …
Molecular alterations during progression of prostate cancer to androgen independence
BACKGROUND Prostate cancer is the most commonly diagnosed cancer among men in
North America and is a leading cause of death. Standard treatments include androgen …
North America and is a leading cause of death. Standard treatments include androgen …