Radiotherapy (RT) is a cancer treatment that uses high doses of radiation to kill cancer cells
and shrink tumors. Although great success has been achieved on radiotherapy, there is still …

Angiogenesis is a significant event in a wide range of healthy and diseased conditions. This
process frequently involves vasodilation and an increase in vascular permeability …

Cancer is one of the leading causes of death globally, associated with multifactorial
pathophysiological components. In particular, genetic mutations, infection or inflammation …

Tumor cells recruit vascular endothelial cells and circulating endothelial progenitor cells to
form new vessels to support their own growth and metastasis. VEGF, PDGF-BB and FGF-2 …

The cardiovascular system ensures the delivery of oxygen and nutrients to all cells, tissues,
and organs. Under extended exposure to reduced oxygen levels, cells are able to survive …

Simple Summary Integrins, a superfamily of cell adhesion receptors, were extensively
investigated as therapeutic targets over the last decades, motivated by their multiple …

Cancer is a key health issue across the world, causing substantial patient morbidity and
mortality. Patient prognosis is tightly linked with metastatic dissemination of the disease to …

Abrogating tumor angiogenesis by inhibiting vascular endothelial growth factor receptor‐2
(VEGFR 2) has been established as a therapeutic strategy for treating cancer. However …

Metastasis represents a serious complication in the treatment of cancer. Flavonoids are
plant secondary metabolites exerting various health beneficiary effects. The effects of …

Celastrol, a natural bioactive ingredient derived from Tripterygium wilfordii Hook F, exhibits
significant broad-spectrum anticancer activities for the treatment of a variety of cancers …