Mesenchymal stem cells (MSCs) have recently been shown to home to tumors and
contribute to the formation of the tumor-associated stroma. In addition, MSCs can secrete …

Deregulated angiogenesis has been identified as a key contributor in a number of
pathological conditions including cancer. It is a complex process, which involves highly …

Osteosarcoma (OS) is a type of malignant primary bone cancer, which is highly aggressive
and occurs more commonly in children and adolescents. Thus, novel potential drugs and …

The concept that blood supply is required and necessary for cancer growth and spreading is
intuitive and was firstly formalized by Judah Folkman in 1971, when he demonstrated that …

Oral squamous cell carcinoma (OSCC), accounting for two-thirds of head and neck cancer,
is characterized by poor prognosis and a high rate of mortality. Exosomes have emerged as …

In recent years, the interest in natural compounds exerting immunoregulatory effects has
enormously increased. Among these, the polyphenol resveratrol, found in a variety of foods …

Melatonin exerts antimetastatic effects on liver and breast cancer and also inhibits matrix
metalloproteinase (MMP) activity. However, the detailed impacts and underlying …

Induction of thrombosis in tumor vasculature represents an appealing strategy for combating
cancer. Formation of fibrin clots may be sufficient to occlude the blood vessels that feed …

Morbidity and mortality owing to hepatocellular carcinoma (HCC), the most common primary
liver cancer, has increased in recent years. Curcumin is a polyphenol compound that has …

Obesity-related inflammation promotes cancer development. Tissue resident macrophages
affect tumor progression and the tumor micro-environment favors polarization into …