Microfluidic single-cell manipulation and analysis: Methods and applications

T Luo, L Fan, R Zhu, D Sun - Micromachines, 2019 - mdpi.com
In a forest of a hundred thousand trees, no two leaves are alike. Similarly, no two cells in a
genetically identical group are the same. This heterogeneity at the single-cell level has been …

Microfluidic electrochemical devices for pollution analysis–A review

J Kudr, O Zitka, M Klimanek, R Vrba, V Adam - Sensors and Actuators B …, 2017 - Elsevier
Pollution of environment represents serious issue, which deserves increased attention.
Conventional laboratory techniques, which rely on bench-top devices, do not satisfy …

Microfluidic deformability cytometry: A review

Y Chen, K Guo, L Jiang, S Zhu, Z Ni, N Xiang - Talanta, 2023 - Elsevier
Cell deformability plays an important role in cellular processes and functions, including cell
growth and differentiation, as well as cell transfer and cell cycle. Measuring deformability at …

[PDF][PDF] Cellular analysis using microfluidics

J Sibbitts, KA Sellens, S Jia, SA Klasner… - Analytical …, 2017 - par.nsf.gov
Cells are the fundamental building blocks of life. Changes within a cell can propagate
throughout much larger, more complex systems. The knowledge of how these changes arise …

[PDF][PDF] Automated measurement of cell mechanical properties using an integrated dielectrophoretic microfluidic device

H Yang, M Zhu, T Chen, F Niu, L Sun, L Cheng - Iscience, 2022 - cell.com
Cell mechanics is closely related to and interacts with cellular functions, which has the
potential to be an effective biomarker to indicate disease onset and progression. Although …

Characterization of biomechanical properties of cells through dielectrophoresis-based cell stretching and actin cytoskeleton modeling

G Bai, Y Li, HK Chu, K Wang, Q Tan, J Xiong… - Biomedical engineering …, 2017 - Springer
Background Cytoskeleton is a highly dynamic network that helps to maintain the rigidity of a
cell, and the mechanical properties of a cell are closely related to many cellular functions …

Microfluidic techniques for mechanical measurements of biological samples

PF Salipante - Biophysics Reviews, 2023 - pubs.aip.org
The use of microfluidics to make mechanical property measurements is increasingly
common. Fabrication of microfluidic devices has enabled various types of flow control and …

Micropipette aspiration of single cells for both mechanical and electrical characterization

H Pu, N Liu, J Yu, Y Yang, Y Sun… - IEEE Transactions …, 2019 - ieeexplore.ieee.org
Cellular physical properties have been identified to reflect cell states. Existing techniques
are able to characterize either mechanical or electrical properties of a cell. This paper …

Cell properties assessment using optimized dielectrophoresis-based cell stretching and lumped mechanical modeling

II Hosseini, M Moghimi Zand, AA Ebadi, M Fathipour - Scientific reports, 2021 - nature.com
Cells mechanical property assessment has been a promising label-free method for cell
differentiation. Several methods have been proposed for single-cell mechanical properties …

An inverted dielectrophoretic device for analysis of attached single cell mechanics

RL Urbano, AM Clyne - Lab on a Chip, 2016 - pubs.rsc.org
Dielectrophoresis (DEP), the force induced on a polarizable body by a non-uniform electric
field, has been widely used to manipulate single cells in suspension and analyze their …