Discovery, Structure, and Mechanism of the (R, S)-Norcoclaurine Synthase for the Chiral Synthesis of Benzylisoquinoline Alkaloids
L Zhang, S Zhang, L Liao, H Tang, W Wang, F Yin… - ACS …, 2023 - ACS Publications
Benzylisoquinoline alkaloids (BIAs) are key plant metabolites that offer significant
pharmacological benefits. While most naturally isolated BIAs are identified as (S) …
pharmacological benefits. While most naturally isolated BIAs are identified as (S) …
Pathway elucidation and microbial synthesis of proaporphine and bis-benzylisoquinoline alkaloids from sacred lotus (Nelumbo nucifera)
ME Pyne, ND Gold, VJJ Martin - Metabolic Engineering, 2023 - Elsevier
Sacred lotus (Nelumbo nucifera) has been utilized as a food, medicine, and spiritual symbol
for nearly 3000 years. The medicinal properties of lotus are largely attributed to its unique …
for nearly 3000 years. The medicinal properties of lotus are largely attributed to its unique …
Emerging functions within the enzyme families of plant alkaloid biosynthesis
F Muro-Villanueva, RS Nett - Phytochemistry Reviews, 2023 - Springer
The alkaloids are a major class of nitrogen-containing plant specialized metabolites that
function as both toxic defense compounds and useful pharmaceuticals. Understanding the …
function as both toxic defense compounds and useful pharmaceuticals. Understanding the …
Characterization of two CYP80 enzymes provides insights into aporphine alkaloid skeleton formation in Aristolochia contorta
F Meng, S Zhang, J Su, B Zhu, X Pan, X Qiu… - The Plant …, 2024 - Wiley Online Library
Aporphine alkaloids are a large group of natural compounds with extensive pharmaceutical
application prospects. The biosynthesis of aporphine alkaloids has been paid attentions in …
application prospects. The biosynthesis of aporphine alkaloids has been paid attentions in …
[HTML][HTML] Lotus ( Nelumbo nucifera) benzylisoquinoline alkaloids: advances in chemical profiling, extraction methods, pharmacological activities, and biosynthetic …
X Wei, M Zhang, M Yang, C Ogutu, J Li… - Vegetable …, 2024 - maxapress.com
As a member of the only two species in the Nelumbonaceae family, lotus (Nelumbo nucifera)
accumulates abundant benzylisoquinoline alkaloids (BIAs) in almost all of its tissues …
accumulates abundant benzylisoquinoline alkaloids (BIAs) in almost all of its tissues …
Phylogenetic analysis and functional characterization of norcoclaurine synthase involved in benzylisoquinoline alkaloids biosynthesis in Stephania tetrandra
X Li, Q Li, X Jiao, H Tang, Y Cheng… - Journal of Cellular …, 2023 - Wiley Online Library
Benzylisoquinoline alkaloids (BIAs) are a class of secondary metabolites that possess
diverse pharmaceutical properties and are exclusively accumulated in specific plant genera …
diverse pharmaceutical properties and are exclusively accumulated in specific plant genera …
A biosynthetic network for protoberberine production in Coptis chinensis
L Wu, B Zhao, Z Deng, B Wang, Y Yu - Horticulture Research, 2024 - academic.oup.com
Protoberberine alkaloids are a group of tetracyclic isoquinoline compounds known for their
well-established antimicrobial and anti-inflammatory properties. The richness and diversity …
well-established antimicrobial and anti-inflammatory properties. The richness and diversity …
Identification of the cytochrome P450s responsible for the biosynthesis of two types of aporphine alkaloids and their de novo biosynthesis in yeast
Q Li, X Jiao, X Li, W Shi, Y Ma, X Tan… - Journal of Integrative …, 2024 - Wiley Online Library
Aporphine alkaloids have diverse pharmacological activities; however, our understanding of
their biosynthesis is relatively limited. Previous studies have classified aporphine alkaloids …
their biosynthesis is relatively limited. Previous studies have classified aporphine alkaloids …
[HTML][HTML] Progress on synthesis of benzylisoquinoline alkaloids in sacred lotus (Nelumbo nucifera)
Z Chen, H Zhao, S Chen - Medicinal Plant Biology, 2023 - maxapress.com
Sacred lotus (Nelumbo nucifera) is a 2,000-year-old perennial rhizome aquatic crop that is
primarily employed as a food and drug dual-use crop in East Asia. One of the key bioactive …
primarily employed as a food and drug dual-use crop in East Asia. One of the key bioactive …