Modulation of endogenous cellular defense mechanisms via the vitagene system represents
an innovative approach to therapeutic intervention in diseases causing chronic tissue …

Vitis vinifera (grape) is one of the “most‐produced fruit” in the world. Grape seeds are a
valuable source of phenolic compounds including resveratrol (RSV). Grape and one of its …

Hyperhomocysteinemia (HHcy) is an independent risk factor of atherosclerosis and other
cardiovascular diseases. Unfortunately, Hcy-lowering strategies were found to have limited …

Objectives: Urolithins, ellagitannin-gut microbial-derived metabolites, have been reported to
mediate pomegranate's neuroprotective effects against Alzheimer's disease (AD), but there …

Background: Dietary intake of natural antioxidants is thought to impart protection against
oxidative-associated cardiovascular diseases. Despite many in vivo studies and clinical …

Several studies have demonstrated a relevant role of intestinal epithelial cells in the immune
response and in chronic inflammatory conditions, including ulcers, colitis, and Crohn's …

Aging process is accompanied by hormonal changes characterized by an imbalance
between catabolic hormones, such as cortisol and thyroid hormones which remain stable …

Background Testis is one of the most sensitive organs against the toxic effect of ionizing
radiation. Exposure to even a low dose of radiation during radiotherapy, diagnostic …

Neuroinflammation, a hallmark of chronic neurodegenerative disorders, is characterized by
sustained glial activation and the generation of an inflammatory loop, through the release of …

Background Several results demonstrated that microglia and peripheral monocytes/
macrophages infiltrating the central nervous system (CNS) are involved in cell response …