The role of connexin hemichannels in inflammatory diseases

B Peng, C Xu, S Wang, Y Zhang, W Li - Biology, 2022 - mdpi.com
Simple Summary Connexin hemichannels are formed by connexin protein family members,
and connect cytosol and extracellular milium. The function of connexin hemichannels cannot …

Gap junctions and hemichannels composed of connexins and pannexins mediate the secondary brain injury following intracerebral hemorrhage

Y Zhang, S Khan, Y Liu, R Siddique, R Zhang… - Biology, 2021 - mdpi.com
Simple Summary Intracerebral hemorrhage (ICH) is a leading medical problem without
effective treatment options. The poor prognosis is attributed to the primary brain injury of the …

YAP prevents premature senescence of astrocytes and cognitive decline of Alzheimer's disease through regulating CDK6 signaling

X Xu, X Shen, J Wang, W Feng, M Wang, X Miao… - Aging …, 2021 - Wiley Online Library
Senescent astrocytes accumulate with aging and contribute to brain dysfunction and
diseases such as Alzheimer's disease (AD), however, the mechanisms underlying the …

[HTML][HTML] Astrocytic YAP protects the optic nerve and retina in an experimental autoimmune encephalomyelitis model through TGF-β signaling

Q Wu, X Miao, J Zhang, L Xiang, X Li, X Bao, S Du… - Theranostics, 2021 - ncbi.nlm.nih.gov
Rationale: Optic neuritis is one of main symptoms in multiple sclerosis (MS) that causes
visual disability. Astrocytes are pivotal regulators of neuroinflammation in MS, and astrocytic …

Mechanisms of connexin regulating peptides

DR King, MW Sedovy, X Leng, J Xue… - International Journal of …, 2021 - mdpi.com
Gap junctions (GJ) and connexins play integral roles in cellular physiology and have been
found to be involved in multiple pathophysiological states from cancer to cardiovascular …

Pilot study of cytoprotective mechanisms of selenium nanorods (SeNrs) under ischemia-like conditions on cortical astrocytes

EG Varlamova, EY Plotnikov, IV Baimler… - International Journal of …, 2023 - mdpi.com
The cytoprotective properties of the trace element selenium, its nanoparticles, and selenium
nanocomplexes with active compounds are shown using a number of models. To date …

HMGB1/TLR4 induces autophagy and promotes neuroinflammation after intracerebral hemorrhage

C Lei, Y Li, X Zhu, H Li, X Chang - Brain Research, 2022 - Elsevier
Abstract Background and Purpose Intracerebral hemorrhage (ICH) causes autophagy as
well as inflammation; the latter is known to involve the high-mobility group box 1 protein …

The hallmark and crosstalk of immune cells after intracerebral hemorrhage: Immunotherapy perspectives

W Zhang, Q Wu, S Hao, S Chen - Frontiers in Neuroscience, 2023 - frontiersin.org
Intracerebral hemorrhage (ICH) is one of the most dangerous types of strokes with a high
morbidity and mortality rate. Currently, the treatment of ICH is not well developed, mainly …

Protein kinase B (AKT) upregulation and Thy-1-αvβ3 integrin-induced phosphorylation of Connexin43 by activated AKT in astrogliosis

R Pérez-Núñez, A Chamorro, MF González… - Journal of …, 2023 - Springer
Background In response to brain injury or inflammation, astrocytes undergo hypertrophy,
proliferate, and migrate to the damaged zone. These changes, collectively known as" …

Periodontal ligament fibroblast-derived exosomes induced by compressive force promote macrophage M1 polarization via Yes-associated protein

M Zhao, Q Ma, Z Zhao, X Guan, Y Bai - Archives of Oral Biology, 2021 - Elsevier
Objectives This study aimed to investigate the biological roles and mechanisms of
compressive force-stimulated periodontal ligament fibroblasts (PDLFs) on polarization of …