The role of connexin hemichannels in inflammatory diseases
B Peng, C Xu, S Wang, Y Zhang, W Li - Biology, 2022 - mdpi.com
Simple Summary Connexin hemichannels are formed by connexin protein family members,
and connect cytosol and extracellular milium. The function of connexin hemichannels cannot …
and connect cytosol and extracellular milium. The function of connexin hemichannels cannot …
Gap junctions and hemichannels composed of connexins and pannexins mediate the secondary brain injury following intracerebral hemorrhage
Simple Summary Intracerebral hemorrhage (ICH) is a leading medical problem without
effective treatment options. The poor prognosis is attributed to the primary brain injury of the …
effective treatment options. The poor prognosis is attributed to the primary brain injury of the …
YAP prevents premature senescence of astrocytes and cognitive decline of Alzheimer's disease through regulating CDK6 signaling
X Xu, X Shen, J Wang, W Feng, M Wang, X Miao… - Aging …, 2021 - Wiley Online Library
Senescent astrocytes accumulate with aging and contribute to brain dysfunction and
diseases such as Alzheimer's disease (AD), however, the mechanisms underlying the …
diseases such as Alzheimer's disease (AD), however, the mechanisms underlying the …
[HTML][HTML] Astrocytic YAP protects the optic nerve and retina in an experimental autoimmune encephalomyelitis model through TGF-β signaling
Q Wu, X Miao, J Zhang, L Xiang, X Li, X Bao, S Du… - Theranostics, 2021 - ncbi.nlm.nih.gov
Rationale: Optic neuritis is one of main symptoms in multiple sclerosis (MS) that causes
visual disability. Astrocytes are pivotal regulators of neuroinflammation in MS, and astrocytic …
visual disability. Astrocytes are pivotal regulators of neuroinflammation in MS, and astrocytic …
Mechanisms of connexin regulating peptides
Gap junctions (GJ) and connexins play integral roles in cellular physiology and have been
found to be involved in multiple pathophysiological states from cancer to cardiovascular …
found to be involved in multiple pathophysiological states from cancer to cardiovascular …
Pilot study of cytoprotective mechanisms of selenium nanorods (SeNrs) under ischemia-like conditions on cortical astrocytes
EG Varlamova, EY Plotnikov, IV Baimler… - International Journal of …, 2023 - mdpi.com
The cytoprotective properties of the trace element selenium, its nanoparticles, and selenium
nanocomplexes with active compounds are shown using a number of models. To date …
nanocomplexes with active compounds are shown using a number of models. To date …
HMGB1/TLR4 induces autophagy and promotes neuroinflammation after intracerebral hemorrhage
C Lei, Y Li, X Zhu, H Li, X Chang - Brain Research, 2022 - Elsevier
Abstract Background and Purpose Intracerebral hemorrhage (ICH) causes autophagy as
well as inflammation; the latter is known to involve the high-mobility group box 1 protein …
well as inflammation; the latter is known to involve the high-mobility group box 1 protein …
The hallmark and crosstalk of immune cells after intracerebral hemorrhage: Immunotherapy perspectives
W Zhang, Q Wu, S Hao, S Chen - Frontiers in Neuroscience, 2023 - frontiersin.org
Intracerebral hemorrhage (ICH) is one of the most dangerous types of strokes with a high
morbidity and mortality rate. Currently, the treatment of ICH is not well developed, mainly …
morbidity and mortality rate. Currently, the treatment of ICH is not well developed, mainly …
Protein kinase B (AKT) upregulation and Thy-1-αvβ3 integrin-induced phosphorylation of Connexin43 by activated AKT in astrogliosis
R Pérez-Núñez, A Chamorro, MF González… - Journal of …, 2023 - Springer
Background In response to brain injury or inflammation, astrocytes undergo hypertrophy,
proliferate, and migrate to the damaged zone. These changes, collectively known as" …
proliferate, and migrate to the damaged zone. These changes, collectively known as" …
Periodontal ligament fibroblast-derived exosomes induced by compressive force promote macrophage M1 polarization via Yes-associated protein
M Zhao, Q Ma, Z Zhao, X Guan, Y Bai - Archives of Oral Biology, 2021 - Elsevier
Objectives This study aimed to investigate the biological roles and mechanisms of
compressive force-stimulated periodontal ligament fibroblasts (PDLFs) on polarization of …
compressive force-stimulated periodontal ligament fibroblasts (PDLFs) on polarization of …