The skin, which is comprised of the epidermis, dermis, and subcutaneous tissue, is the
largest organ in the human body and it plays a crucial role in the regulation of the body's …

Melanin is a biological pigment formed by indoles and phenolic compounds. It is widely
found in living organisms and has a variety of unique properties. Due to its diverse …

Ultraviolet radiation (UVR) is primarily recognized for its detrimental effects such as
cancerogenesis, skin aging, eye damage, and autoimmune disorders. With exception of …

Microphthalmia-associated transcription factor (MITF) is an important regulator of
melanogenesis and melanocyte development. Although it has been studied extensively in …

Tyrosinase is a key enzyme target to design new chemical ligands against melanogenesis.
In the current review, different chemical derivatives are explored which have been used as …

The increase in air pollution worldwide represents an environmental risk factor that has
global implications for the health of humans worldwide. The skin of billions of people is …

The skin containing melanin pigment acts as a protective barrier and counteracts the UVR
and other environmental stressors to maintain or restore disrupted cutaneous homeostasis …

Nanosized antioxidants are highly advantageous in terms of versatility and
pharmacokinetics, with respect to conventional molecular ones. Melanin-like materials …

Curcumin, a natural polyphenol widely used as a spice, colorant and food additive, has
been shown to have therapeutic effects against different disorders, mostly due to its anti …

Rationale: Senescent melanocytes accumulate in photoaged skin and are closely related to
skin aging. A better understanding of the molecular characteristics of senescent …