Proteases form one of the largest and more important groups of enzymes. They selectively
catalyze the hydrolysis of peptide bonds and can be divided into four major classes …

Plant-based diets are a great source of protease inhibitors (PIs). Two of the most well-known
families of PIs are Bowman-Birk inhibitors (BBI) and Kunitz-type inhibitors (KTI). The first …

Nonsense-mediated mRNA decay (NMD) limits the production of aberrant mRNAs
containing a premature termination codon and also controls the levels of endogenous …

How cancer cells globally struggle with a chemotherapeutic insult before succumbing to
apoptosis is largely unknown. Here we use an integrated systems-level examination of …

Apoptosis is a highly complex and regulated cell death pathway that safeguards the
physiological balance between life and death. Over the past decade, the role of Ca 2+ …

It is known that many chemotherapeutics induce cellular apoptosis over hours to days.
During apoptosis, numerous cellular proteases are activated, most canonically the …

ABSTRACT A central role of the endoplasmic reticulum (ER) is the synthesis, folding and
quality control of secretory proteins. Secretory proteins usually exit the ER to enter the Golgi …

Cells are in constant adaptation to environmental changes to insure their proper functioning.
When exposed to stresses, cells activate specific pathways to elicit adaptive modifications …

Introduction bluetongue virus (BTV) infection triggers dramatic and complex changes in the
host's transcriptional profile to favor its own survival and reproduction. However, there is no …

Noninvasive detection and in vivo imaging of apoptosis plays a critical role in the
development of therapeutics in many different fields including cancer. We have developed …