Nuclear receptors, also known as ligand-activated transcription factors, regulate gene
expression upon ligand signals and present as attractive therapeutic targets especially in …

Dysfunction of the immune system underlies a plethora of human diseases, requiring the
development of immunomodulatory therapeutic intervention. To date, most strategies …

T cells critically depend on reprogramming of metabolic signatures to meet the bioenergetic
demands during activation and clonal expansion. Here we identify the transcription factor …

Background Neuroinflammation and blood-brain barrier (BBB) disruption are two vital
mechanisms of secondary brain injury following intracerebral hemorrhage (ICH). Recently …

Microglia-mediated neuroinflammation is involved in various neurological diseases,
including ischemic stroke, but the endogenous mechanisms preventing unstrained …

Neuroinflammation plays a pivotal part in the pathogenesis of stroke. Orphan nuclear
receptor NR4A1 is involved in the inflammatory response of microglia and macrophages. In …

Inflammatory activation of glial cells promotes loss of dopaminergic neurons in Parkinson
disease. The transcription factor nuclear factor κB (NF-κ B) regulates the expression of …

Nuclear receptor subfamily 4 group A1 (NR4A1) is an orphan nuclear receptor, which is
expressed in the majority of cells. NR4A1 expression in peripheral blood mononuclear cells …

Background Immunosurveillance of the central nervous system (CNS) is vital to resolve
infection and injury. However, immune activation within the CNS in the setting of chronic …

Nuclear receptor4 group A1 (Nr4a1), an orphan nuclear receptor, is down-regulated in
peripheral blood mononuclear cells (MNCs) of individuals with multiple sclerosis (MS), and …