Social isolation is an established risk factor for psychiatric illness, and became increasingly
topical with the spread of SARS-CoV-2. We used RNA sequencing (RNA-Seq) to enable …

The GABAergic medium-size spiny neuron (MSN), the striatal output neuron, may be
classified into striosome, also known as patch, and matrix, based on neurochemical …

Neonatal hypoxia-ischemia (HI) is a major cause of perinatal death and long-term
disabilities worldwide. Post-ischemic neuroinflammation plays a pivotal role in HI …

Prematurity is associated with perinatal neuroinflammation and injury. Screening for genetic
modulators in an LPS murine model of preterm birth revealed the upregulation of Nr4a1, an …

Investigator-generated transcriptomic datasets interrogating circulating immune cell (CIC)
gene expression in clinical type 1 diabetes (T1D) have underappreciated re-use value …

Glioblastoma (GBM) harbors a highly immunosuppressive tumor microenvironment (TME)
which influences glioma growth. Major efforts have been undertaken to describe the TME on …

Nur77 belongs to the NR4A subgroup of the nuclear receptor superfamily. Unlike other
nuclear receptors, a natural ligand for Nur77 has not been identified yet. However, a few …

Oxidative stress plays a significant role in the development of Parkinson's disease (PD).
Previous studies implicate nuclear receptor subfamily 4 group A member 1 (NR4A1) in …

Microglia are key mediators of inflammatory responses within the brain, as they regulate pro-
inflammatory responses while also limiting neuroinflammation via reparative phagocytosis …

Focal cerebral ischemia is a major cardiovascular disease that seriously threatens human
health. Its neuromodulator is sodium butyrate, whose underlying mechanisms remain …