Chimeric antigen receptor-natural killer cell therapy: current advancements and strategies to overcome challenges

JC Kong, MA Sa'ad, HM Vijayan… - Frontiers in …, 2024 - frontiersin.org
Chimeric antigen receptor-natural killer (CAR-NK) cell therapy is a novel immunotherapy
targeting cancer cells via the generation of chimeric antigen receptors on NK cells which …

S309-CAR-NK cells bind the Omicron variants in vitro and reduce SARS-CoV-2 viral loads in humanized ACE2-NSG mice

MT Ma, Q Jiang, CH Chen, S Badeti, X Wang… - Journal of …, 2024 - Am Soc Microbiol
Recent progress on chimeric antigen receptor (CAR)-NK cells has shown promising results
in treating CD19-positive lymphoid tumors with minimal toxicities [including graft versus host …

[HTML][HTML] Cutting-edge CAR engineering: beyond T cells

L Chocarro, E Blanco, L Fernández-Rubio, H Arasanz… - Biomedicines, 2022 - mdpi.com
Chimeric antigen receptor (CAR)-T adoptive cell therapy is one of the most promising
advanced therapies for the treatment of cancer, with unprecedented outcomes in …

Ancient human endogenous retroviruses contribute to genetic evolution and regulate cancer cell type–specific gene expression

M Chen, L Jia, X Zheng, M Han, L Li, L Zhang - Cancer Research, 2022 - AACR
Human endogenous retroviruses (HERV), a type of transposable elements (TE), play crucial
roles in human placental morphogenesis, immune response, and cancer progression …

Expanded clinical-grade NK cells exhibit stronger effects than primary NK cells against HCMV infection

QN Shang, XX Yu, ZL Xu, YH Chen, TT Han… - Cellular & Molecular …, 2023 - nature.com
Cytomegalovirus (CMV) reactivation remains a common complication and leads to high
mortality in patients who undergo allogeneic hematopoietic stem cell transplantation (allo …

Interleukin-21 as an adjuvant in cancer immunotherapy: Current advances and future directions

X Li, M Wu, J Lu, J Yu, D Chen - … et Biophysica Acta (BBA)-Reviews on …, 2024 - Elsevier
Immunotherapy has revolutionized cancer treatment. However, it's well-recognized that a
considerable proportion of patients fail to benefit from immunotherapy, and to improve …

[HTML][HTML] A Critical Role of Culture Medium Selection in Maximizing the Purity and Expansion of Natural Killer Cells

N Kusch, J Storm, A Macioszek, E Kisselmann… - Cells, 2024 - mdpi.com
Natural killer (NK) cells hold promise in cancer treatment due to their ability to
spontaneously lyse cancer cells. For clinical use, high quantities of pure, functional NK cells …

Expansion of KRAS hotspot mutations reactive T cells from human pancreatic tumors using autologous T cells as the antigen-presenting cells

S Wang, X Zhang, X Zou, M Wen, C Gan… - Cancer Immunology …, 2023 - Springer
Adoptive cell therapy (ACT) with expanded tumor-infiltrating lymphocytes (TIL) or TCR gene-
modified T cells (TCR-T) that recognize mutant KRAS neo-antigens can mediate tumor …

[HTML][HTML] 两种扩增体系NK 细胞生物学特性比较及治疗异基因造血干细胞移植后白血病复发的初步研究

曹勋红, 王志东, 孙于谦, 孔军, 卢晟晔… - Chinese Journal of …, 2022 - ncbi.nlm.nih.gov
两种扩增体系NK细胞生物学特性比较及治疗异基因造血干细胞移植后白血病复发的初步研究-
PMC Back to Top Skip to main content NIH NLM Logo Access keys NCBI Homepage MyNCBI …

[HTML][HTML] Autologous ex vivo expanded NK cells combined with PD-1 inhibitor improved ascitic fluid immune microenvironment of peritoneal metastatic pancreatic …

L Chen, Y Qian, M Guo, Y Liu, J Li, M Wu… - American Journal of …, 2023 - ncbi.nlm.nih.gov
The presence of peritoneal metastasis in patients with pancreatic cancer is associated with
poor prognosis. Chemotherapy and radiotherapy may result in poor prognosis in patients …