Sufficiently activated mature natural killer cells derived from peripheral blood mononuclear cells substantially enhance antitumor activity
C Liu, Y Li, Y Li, M Hu, H Wang, S Lu… - Immunity …, 2024 - Wiley Online Library
Background Peripheral blood‐derived natural killer (NK) cells spontaneously lyse tumor
cells without prior sensitization. However, NK cells in peripheral blood (PBNK cells) are in a …
cells without prior sensitization. However, NK cells in peripheral blood (PBNK cells) are in a …
Preclinical studies of chimeric antigen receptor-modified natural killer cells in cancer immunotherapy: a review
M Hosseini, Z Habibi, N Hosseini, S Abdoli… - Expert Opinion on …, 2022 - Taylor & Francis
Introduction As one of the most efficacious methods of cancer immunotherapy, chimeric
antigen receptor-modified immune cells have recently drawn enormous attention. After the …
antigen receptor-modified immune cells have recently drawn enormous attention. After the …
CAR-NK cells effectively target the D614 and G614 SARS-CoV-2-infected cells
ABSTRACT Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is highly
contagious presenting a significant public health issue. Current therapies used to treat …
contagious presenting a significant public health issue. Current therapies used to treat …
Mesenchymal Stromal Cells Increase the Natural Killer Resistance of Circulating Tumor Cells via Intercellular Signaling of cGAS‐STING‐IFNβ‐HLA
Circulating tumor cells (CTCs) shed from primary tumors must overcome the cytotoxicity of
immune cells, particularly natural killer (NK) cells, to cause metastasis. The tumor …
immune cells, particularly natural killer (NK) cells, to cause metastasis. The tumor …
Natural killer (NK) and CAR-NK cell expansion method using membrane bound-IL-21-modified B cell line
Chimeric antigen receptor (CAR)-modified immune cell therapy has become an emerging
treatment for cancers and infectious diseases. NK-based immunotherapy, particularly CAR …
treatment for cancers and infectious diseases. NK-based immunotherapy, particularly CAR …
Development of Genetically Engineered Feeder Cells for Natural Killer Cell Expansion
LEE DA YEON, Y Kim, JS Park, JU Choi… - Anticancer …, 2023 - ar.iiarjournals.org
Background/Aim: To obtain sufficient numbers of high-quality natural killer (NK) cells, we
developed feeder cells using synthetic biology techniques. Materials and Methods: K562 …
developed feeder cells using synthetic biology techniques. Materials and Methods: K562 …
“Off the Shelf” CAR‐T/NK Cells
Off‐the‐shelf T and NK cell‐based strategies are the of future allogeneic cellular therapies,
as they overcome most of the current limitations associated with classical CAR‐T cell …
as they overcome most of the current limitations associated with classical CAR‐T cell …
Phenotypic and functional characterisation of locally produced natural killer cells ex vivo expanded with the K562-41BBL-mbIL21 cell line
TV Shman, KP Vashkevich, AA Migas… - Clinical and …, 2023 - Springer
We characterised the expansion, phenotype and functional activity of natural killer (NK) cells
obtained for a clinical trial. Nineteen expansion procedures were performed to obtain NK …
obtained for a clinical trial. Nineteen expansion procedures were performed to obtain NK …
Natural Killer Cell Dysfunction In Human Bladder Cancer Is Caused By Tissue-Specific Suppression of SLAMF6 Signaling
NK cells are innate lymphocytes critical for surveillance of viruses and tumors, however the
mechanisms underlying NK cell dysfunction in cancer are incompletely understood. We …
mechanisms underlying NK cell dysfunction in cancer are incompletely understood. We …
CAR-NK cell immunotherapy: Development and challenges toward an off-the-shelf product
Chimeric antigen receptor (CAR)-T cells have emerged as a novel immunotherapy that has
redefined cancer treatment. Despite its clinical success, this therapy has many limitations …
redefined cancer treatment. Despite its clinical success, this therapy has many limitations …