Exploring Glypican-3 Targeted CAR-NK Treatment and Potential Therapy Resistance in Hepatocellular Carcinoma

L Yang, K Pham, Y Xi, Q Wu, D Liu… - Authorea …, 2024 - advance.sagepub.com
Exploring Glypican-3 Targeted CAR-NK Treatment and Potential Therapy Resistance in
Hepatocellular Carcinoma Page 1 P osted on 30 Jan 2024 — The cop yrigh t holder is the …

[PDF][PDF] Estrategias para la mejora de la persistencia y la eficacia de las células CAR NK para el tratamiento del mieloma múltiple refractario y en recaída Strategies to …

JE Mayoral - 2024 - docta.ucm.es
El mieloma múltiple (MM) es una neoplasia caracterizada por la proliferación clonal de
células plasmáticas patológicas, principalmente en la médula ósea. Constituye el 10% de …

Human Primary NK Cells from Humanized BLT-IL15 Mice Show Superior Expansion and Cytotoxicity in Comparison with Humanized BLT-mice Using Membrane …

Y Yang, J Zhang, M Ma, Y Cheng, SC Lohani… - Authorea …, 2024 - essopenarchive.org
Background: Natural Killer (NK) cells play a critical role in host defense. Studying human NK
immunobiology is mainly focused on using in vitro assays with limited NK cells from …

Estrategias para la mejora de la persistencia y la eficacia de las células CAR NK para el tratamiento del mieloma múltiple refractario y en recaída

J Encinas Mayoral - 2024 - docta.ucm.es
El mieloma múltiple (MM) es una neoplasia caracterizada por la proliferación clonal de
células plasmáticas patológicas, principalmente en la médula ósea. Constituye el 10% de …

Development of a scalable and robust upstream process for the chemically-defined production of lentiviral vectors for gene-modified cellular immunotherapies

C Ripoll Fiol - 2024 - discovery.ucl.ac.uk
Ex vivo gene-modified cellular immunotherapy, including chimeric antigen receptor (CAR)-T
and CAR-NK cell therapy, is a promising therapeutic modality for the treatment of various …

NK cells and Cd8 T cells in cancer Immunotherapy: similar functions by different mechanisms

C Dunai, CP Collins, I Barao, WJ Murphy - Successes and Challenges of …, 2021 - Elsevier
Abstract NK cells and CD8 T cells are cytotoxic lymphocytes that have critical protective
roles against pathogens and cancers. NK cells are conventionally regarded as rapid-acting …

Increasing specificity and overcoming hypoxia in the tumor microenvironment to optimize anti-tumor activity of human natural killer cells

US Arvindam - 2022 - search.proquest.com
Natural Killer (NK) cells are cytotoxic innate immune cells that are important components of
anti-tumor immunity. They make up 5-15% of total lymphocytes and are derived from the …

NK Cell Line Based Therapy

RD Discov - Precision Cancer Therapies - Wiley Online Library
NK-92 and YT NK cell lines have been tested as sources of allo NK cells for cellular
therapies. NK-92 is a highly cytotoxic tumor cell line derived from a patient with NK …

Comparison of the characteristics of NK cells after two different methods of expansion and observation of the clinical efficacy in patients who relapsed post allogeneic …

XH Cao, ZD Wang, YQ Sun, J Kong, SY Lu… - Zhonghua xue ye xue …, 2022 - europepmc.org
Objective: To explore the differences in the biological effects of different expansion systems
on natural killer (NK) cells, as well as the safety and preliminary clinical efficacy in the …

Nk and T Cell Responses during Acute Mouse Cytomegalovirus Infection

C Dunai - 2021 - search.proquest.com
Mouse cytomegalovirus (MCMV) is a herpes virus that provides a useful model for studying
viral pathogenesis in multiple organs following a primary infection. It also enables tracking of …