Aging, as a complex process involving multiple cellular and molecular pathways, is known to
be exacerbated by various stresses. Because responses to these stresses, such as oxidative …

Alzheimer's disease (AD) and other forms of dementia represent major public health
challenges but effective therapeutic options are limited. Pathological brain aging is …

The ribotoxic stress response (RSR) is a signaling pathway in which the p38-and c-Jun N-
terminal kinase (JNK)–activating mitogen-activated protein kinase kinase kinase (MAP3K) …

By definition, aging is a natural, gradual and continuous process. On the other hand, frailty
reflects the increase in vulnerability to stressors and shortens the time without disease …

We define aging as a characteristic deterioration in one (or more) observable attributes of an
organism that typically occurs during later life. With this narrow functional definition, we gain …

On average, aging is associated with unfavorable changes in cellular metabolism, which are
the processes involved in the storage and expenditure of energy. However, metabolic …

Aging is a complex biological process characterized by a progressive loss of physiological
integrity and increased vulnerability to age-related diseases. Adipose tissue plays central …

In females, there is a continuous decline of the ovarian reserve with age, which results in
menopause in women or estropause in mice. Loss of ovarian function results in metabolic …

Insight into associations between the gut microbiome with metabolism and aging is crucial
for tailoring interventions to promote healthy longevity. In a discovery cohort of 10,207 …

Background The gut microbiota plays a crucial role in regulating the host's immune
responses during aging, which was characterized by a different abundance of bacteria in …