Abstract Sotatercept (ACE-011) is an activin receptor IIA-Fc (ActRIIA-Fc) fusion protein
currently under investigation for its potential in the treatment of hematologic diseases. By …

Chronic myelomonocytic leukemia (CMML) is a rare clonal haematological malignancy
bearing characteristics of both myelodysplastic syndromes and myeloproliferative …

Simple Summary Chronic myelomonocytic leukemia (CMML) is an infrequent disease with
poor prognosis and risk of progression into acute myeloid leukemia (AML). Stem cell …

Background: Leukemia, a cancer impacting blood-forming tissues such as bone marrow and
the lymphatic system, presents in various forms, affecting children and adults differently. The …

Although CMML since long has been separated from MDS, many studies continue to
evaluate the outcomes of both diseases after hematopoietic cell transplantation (allo‐HCT) …

Myeloid leukemias are a broad group of hematological disorders, characterized by
heterogeneous clinical and biological features. In recent years, unprecedented genetic …

Untangling Systemic Mastocytosis: An Update on Challenges in the Diagnosis and Treatment of
Myeloid Neoplasms with Systemic Mast Page 1 Untangling Systemic Mastocytosis: An Update …

Alternative statistical designs cannot fully mitigate the limitations of traditional clinical trials in
rare cancers. Creative study designs that integrate early clinical data and correlative …

Chronic Myelomonocytic Leukemia (CMML) is a hematologic malignancy classified as an
overlapping Myelodysplastic Syndrome/Myeloproliferative Neoplasm (MDS/MPN) that can …

Leukemia, the cancer of blood cells, originates in the blood-forming cells of the bone
marrow. In Chronic Myeloid Leukemia (CML) conditions, the cells partially become mature …