The Janus kinase/signal transducer and activator of transcription (JAK/STAT) signaling
pathway was discovered more than a quarter-century ago. As a fulcrum of many vital cellular …

The aberrant Wnt/β-catenin signaling pathway facilitates cancer stem cell renewal, cell
proliferation and differentiation, thus exerting crucial roles in tumorigenesis and therapy …

Piperidines are among the most important synthetic fragments for designing drugs and play
a significant role in the pharmaceutical industry. Their derivatives are present in more than …

Human malignancies are one of the major health-related issues though out the world and
anticipated to rise in the future. The development of novel drugs/agents requires a huge …

Increasing evidence suggests that traditional Chinese medicine strategies are obviously
beneficial for cancer treatment, but scientific research on the underlying molecular …

Background Colorectal cancer (CRC) is a highly prevalent cancer type with limited targeted
therapies available and 5-year survival rate, particularly for late-stage patients. There have …

Psychotropic drugs can penetrate the blood–brain barrier and regulate the levels of
neurotransmitters and neuromodulators such as γ-aminobutyric acid, glutamate, serotonin …

Background and Purpose: Drug repositioning is a promising strategy for discovering new
therapeutic strategies for cancer therapy. We investigated psychotropic drugs for their …

Worldwide, prostate cancer (PC) is the second most frequent cancer among men and the
fifth leading cause of death; moreover, standard treatments for PC have several issues, such …

Over a century ago, the phenothiazine dye, methylene blue, was discovered to have both
antipsychotic and anti-cancer effects. In the 20th-century, the first phenothiazine …