The association of human herpesviruses with malignant brain tumor pathology and therapy: two sides of a coin
E Athanasiou, AN Gargalionis, F Boufidou… - International Journal of …, 2021 - mdpi.com
The role of certain viruses in malignant brain tumor development remains controversial.
Experimental data demonstrate that human herpesviruses (HHVs), particularly …
Experimental data demonstrate that human herpesviruses (HHVs), particularly …
Temozolomide-induced myelotoxicity and single nucleotide polymorphisms in the MGMT gene in patients with adult diffuse glioma: a single-institutional …
P Moitra, A Chatterjee, PK Kota, S Epari, V Patil… - Journal of Neuro …, 2022 - Springer
Purpose Nearly 10% of patients with adult diffuse glioma develop clinically significant
myelotoxicity while on temozolomide (TMZ) leading to treatment interruptions. This study …
myelotoxicity while on temozolomide (TMZ) leading to treatment interruptions. This study …
MGMT in glial carcinogenesis. Roles from prevention to treatment
Many investigations exist regarding the effect of the DNA repair enzyme MGMT (O 6-
methylguanine-DNA-methyltransferase)-encoding gene methylation on the antineoplasticity …
methylguanine-DNA-methyltransferase)-encoding gene methylation on the antineoplasticity …
Evaluation of mutations on O6-methylguanine methyl transferase structure and its interactions: molecular dynamics simulation study
M Gharouni, H Mosaddeghi - Journal of Biomolecular Structure and …, 2023 - Taylor & Francis
O6-methylguanine DNA methyl transferase (MGMT) is a significant vehicle for the cellular
clearance of alkyl lesions, particularly the methyl group of the O-6 and O-4 positions of …
clearance of alkyl lesions, particularly the methyl group of the O-6 and O-4 positions of …
Brain radiotoxicity-related 15CAcBRT gene expression signature predicts survival prognosis of glioblastoma patients
J Reyes-González, F Barajas-Olmos… - Neuro …, 2023 - academic.oup.com
Background Glioblastoma is the most common and devastating primary brain cancer.
Radiotherapy is standard of care; however, it is associated with brain radiation toxicity …
Radiotherapy is standard of care; however, it is associated with brain radiation toxicity …
[HTML][HTML] Long-lasting thrombocytopenia after transient pancytopenia induced by short-term concomitant radiotherapy and temozolomide
A Stepanović, M Nikitović, A Bogdanović… - European Journal of …, 2020 - ncbi.nlm.nih.gov
We describe long-lasting and incompletely resolved thrombocytopenia after transient
profound pancytopenia in a 62-year-old female patient with glioblastoma after short-term …
profound pancytopenia in a 62-year-old female patient with glioblastoma after short-term …
Adjuvant chemotherapy after severe myelotoxicity during chemoradiation phase in malignant gliomas. Is it feasibile? Results from AINO study (Italian Association for …
V Villani, E Anghileri, L Prosperini, G Lombardi… - Journal of …, 2021 - Springer
Background Malignant gliomas (MG) are aggressive brain tumours in adults. The standard
of care is concurrent radiation plus temozolomide (TMZ)[chemo-radiotherapy (CRT)] …
of care is concurrent radiation plus temozolomide (TMZ)[chemo-radiotherapy (CRT)] …
Early platelet variation during concomitant chemo-radiotherapy predicts adjuvant temozolomide-induced thrombocytopenia in newly diagnosed glioblastoma patients
M Fontanilles, F Marguet, C Alexandru… - Supportive Care in …, 2019 - Springer
Purpose Temozolomide (TMZ) is known to induce thrombocytopenia but no early predictive
test has yet been clearly established. The aim of the study was to retrospectively identify and …
test has yet been clearly established. The aim of the study was to retrospectively identify and …
Deleterious impact of a generic temozolomide formulation compared with brand‐name product on the kinetic of platelet concentration and survival in newly diagnosed …
M Fontanilles, A Fontanilles, N Massy… - Fundamental & …, 2020 - Wiley Online Library
Chemo‐induced thrombocytopenia is a limiting toxicity among patients receiving
temozolomide (TMZ) as first‐line treatment for glioblastoma. We aimed to compare early …
temozolomide (TMZ) as first‐line treatment for glioblastoma. We aimed to compare early …
Impact of rs12917 MGMT Polymorphism on [18F]FDG-PET Response in Pediatric Hodgkin Lymphoma (PHL)
S Kewitz-Hempel, L Kurch, M Cepelova… - Molecular Imaging and …, 2019 - Springer
Purpose The enzyme O6-methylguanine-DNA methyltransferase (MGMT) is an important
component of the DNA repair machinery. MGMT removes O6-methylguanine from the DNA …
component of the DNA repair machinery. MGMT removes O6-methylguanine from the DNA …