[HTML][HTML] PIWI-interacting RNA-17458 is oncogenic and a potential therapeutic target in cervical cancer
L Liu, L Li, W Zu, J Jing, G Liu, T Sun, Q Xie - Journal of Cancer, 2023 - ncbi.nlm.nih.gov
Cervical cancer (CC) is one of the leading cancers among the female reproductive system.
The piwi-interacting RNA (piRNA) function and biogenesis has been studied in various …
The piwi-interacting RNA (piRNA) function and biogenesis has been studied in various …
Emerging therapeutic strategies in cancer therapy by HDAC inhibition as the chemotherapeutic potent and epigenetic regulator
D Karati, S Mukherjee, S Roy - Medical Oncology, 2024 - Springer
In developing new cancer medications, attention has been focused on novel epigenetic
medicines called histone deacetylase (HDAC) inhibitors. Our understanding of cancer …
medicines called histone deacetylase (HDAC) inhibitors. Our understanding of cancer …
Molecular targets and therapeutic strategies for triple-negative breast cancer
Y Bhat, MR Thrishna, S Banerjee - Molecular Biology Reports, 2023 - Springer
Triple-negative breast cancer (TNBC) is known for its heterogeneous complexity and is often
difficult to treat. TNBC lacks the expression of major hormonal receptors like estrogen …
difficult to treat. TNBC lacks the expression of major hormonal receptors like estrogen …
Apigenin and its combination with Vorinostat induces apoptotic-mediated cell death in TNBC by modulating the epigenetic and apoptotic regulators and related …
S Nimal, N Kumbhar, Saruchi, S Rathore, N Naik… - Scientific Reports, 2024 - nature.com
Triple-negative breast cancer (TNBC) is a metastatic disease and a formidable treatment
challenge as it does not respond to existing therapies. Epigenetic regulators play a crucial …
challenge as it does not respond to existing therapies. Epigenetic regulators play a crucial …
Multitargeting HDAC Inhibitors Containing a RAS/RAF Protein Interfering Unit
Y Wang, J Zhang, K Li, S Xia, S Gou - Journal of Medicinal …, 2024 - ACS Publications
In this work, a series of multitargeting histone deacetylase (HDAC) inhibitors capable of
regulating the signal transduction between RAS protein and downstream effectors were …
regulating the signal transduction between RAS protein and downstream effectors were …
Epigenetic Dysregulation and Its Correlation with the Steroidogenic Machinery Impacting Breast Pathogenesis: Data Mining and Molecular Insights into Therapeutics
PR Manna, S Yang, PH Reddy - International Journal of Molecular …, 2023 - mdpi.com
Breast cancer (BC) is a heterogeneous condition and comprises molecularly distinct
subtypes. An imbalance in the levels of epigenetic histone deacetylases (HDACs) …
subtypes. An imbalance in the levels of epigenetic histone deacetylases (HDACs) …
[HTML][HTML] Exploring the pharmacokinetic properties and inhibitory potentials of plant-derived alkaloids against nuclear protein targets in triple-negative breast cancer …
Triple-negative breast cancer (TNBC) overexpresses poly-ADP ribose-polymerase (PARP),
and histone deacetylase (HDAC) specific isoforms, PARP2 and HDAC7 respectively. There …
and histone deacetylase (HDAC) specific isoforms, PARP2 and HDAC7 respectively. There …