[HTML][HTML] Oral delivery of therapeutic peptides and proteins: Technology landscape of lipid-based nanocarriers

S Haddadzadegan, F Dorkoosh… - Advanced drug delivery …, 2022 - Elsevier
The oral administration of therapeutic peptides and proteins is favoured from a patient and
commercial point of view. In order to reach the systemic circulation after oral administration …

[HTML][HTML] Oral delivery of proteins and peptides: Challenges, status quo and future perspectives

Q Zhu, Z Chen, PK Paul, Y Lu, W Wu, J Qi - Acta Pharmaceutica Sinica B, 2021 - Elsevier
Proteins and peptides (PPs) have gradually become more attractive therapeutic molecules
than small molecular drugs due to their high selectivity and efficacy, but fewer side effects …

Surface modification of lipid-based nanoparticles

Y Xu, T Fourniols, Y Labrak, V Préat, A Beloqui… - ACS …, 2022 - ACS Publications
There is a growing interest in the development of lipid-based nanocarriers for multiple
purposes, including the recent increase of these nanocarriers as vaccine components …

An overview of in vitro, ex vivo and in vivo models for studying the transport of drugs across intestinal barriers

Y Xu, N Shrestha, V Préat, A Beloqui - Advanced Drug Delivery Reviews, 2021 - Elsevier
Oral administration is the most commonly used route for drug delivery owing to its cost-
effectiveness, ease of administration, and high patient compliance. However, the absorption …

Advances in oral absorption of polysaccharides: Mechanism, affecting factors, and improvement strategies

Z Zheng, X Pan, L Luo, Q Zhang, X Huang, Y Liu… - Carbohydrate …, 2022 - Elsevier
Polysaccharides have been widely used as biomaterials and drugs after oral administration
due to their suitable physicochemical properties, good bioactivities and low toxicities …

Potential of insulin nanoparticle formulations for oral delivery and diabetes treatment

CY Wong, H Al-Salami, CR Dass - Journal of controlled release, 2017 - Elsevier
Nanoparticles have demonstrated significant advancements in potential oral delivery of
insulin. In this publication, we review the current status of polymeric, inorganic and solid-lipid …

Overcoming the intestinal barrier: a look into targeting approaches for improved oral drug delivery systems

Y Xu, N Shrestha, V Préat, A Beloqui - Journal of controlled release, 2020 - Elsevier
Oral drug administration is one of the most preferred and simplest routes among both
patients and formulation scientists. Nevertheless, orally delivery of some of the most widely …

Lipid-based nanocarriers for oral peptide delivery

Z Niu, I Conejos-Sánchez, BT Griffin… - Advanced drug delivery …, 2016 - Elsevier
This article is aimed to overview the lipid-based nanostructures designed so far for the oral
administration of peptides and proteins, and to analyze the influence of their composition …

Nanoparticle delivery systems in the treatment of diabetes complications

EB Souto, SB Souto, JR Campos, P Severino… - Molecules, 2019 - mdpi.com
Diabetes mellitus, an incurable metabolic disease, is characterized by changes in the
homeostasis of blood sugar levels, being the subcutaneous injection of insulin the first line …

[HTML][HTML] Advances in oral peptide drug nanoparticles for diabetes mellitus treatment

Y Li, W Zhang, R Zhao, X Zhang - Bioactive Materials, 2022 - Elsevier
Peptide drugs play an important role in diabetes mellitus treatment. Oral administration of
peptide drugs is a promising strategy for diabetes mellitus because of its convenience and …