The CCL2-CCR2 axis is one of the major chemokine signaling pathways that has received
special attention because of its function in the development and progression of …

Tumour-Associated Macrophages (TAMs) are one of the pivotal components of the tumour
microenvironment. Their roles in the cancer immunity are complicated, both pro-tumour and …

Chemokines are a family of cytokines that orchestrate the migration and positioning of
immune cells within tissues and are critical for the function of the immune system. CCR2 …

Abstract S100A8 and S100A9 are Ca 2+ binding proteins that belong to the S100 family.
Primarily expressed in neutrophils and monocytes, S100A8 and S100A9 play critical roles in …

Cancer is a multi-step disease caused by the accumulation of genetic mutations and/or
epigenetic changes, and is the biggest challenge around the world. Cytokines, including …

In the tumor microenvironment (TME), tumor-associated macrophages (TAMs) are the most
abundant immune cells, which act as a key regulator in tumorigenesis and progression …

Colorectal cancer (CRC) is one of the most frequent tumor entities worldwide with only
limited therapeutic options. CRC is not only a genetic disease with several mutations in …

The complexity and plasticity of the tumor microenvironment (TME) make it difficult to fully
understand the intratumoral regulation of different cell types and their activities …

Tumor-associated macrophages (TAMs) constitute the most prolific resident of the tumor
microenvironment (TME) that regulate its TME into tumor suppressive or progressive milieu …

Immune checkpoint inhibitors induce significant and durable treatment responses in about
20% of all cancers, but many patients have natural resistance to current immunotherapies …