The mechanism of action of the combination therapy, naltrexone/bupropion (NB), for obesity
has not been fully described to date. Weight loss attempts rarely result in long-term success …

Overconsumption of high caloric food plays an important role in the etiology of obesity.
Several factors drive such hedonic feeding. High caloric food is often palatable. In addition …

Dr. David A. Kessler, the dynamic and controversial former FDA commissioner known for his
crusade against the tobacco industry, is taking on another business that's making Americans …

The ventral pallidum (VP) is posited to contribute to reward seeking by conveying upstream
signals from the nucleus accumbens (NAc). Yet, very little is known about how VP neuron …

This paper is the 29th consecutive installment of the annual review of research concerning
the endogenous opioid system, now spanning 30 years of research. It summarizes papers …

Background Rodent models highlight the key role of μ-opioid receptor (MOR) signaling in
palatable food consumption. In humans, however, the effects of MOR stimulation on eating …

The opioid receptor antagonist naltrexone (NTX) is one of few approved treatments for
alcoholism, yet the mechanism by which it reduces drinking remains unclear. In rats, NTX …

Chronic social defeat stress, a depression model in rats, reduced struggling in the forced
swimming test dependent on a hedonic trait-stressed rats with high sucrose intake struggled …

Introduction: Obesity is a known health risk for the development of several preventable
diseases. Obesity-related metabolic alterations negatively impact different physiological …

This review is part of a special issue dedicated to Opioid addiction, and examines the
influential role of opioid peptides, opioid receptors and opiate drugs in mediating food intake …