In recent years, the worldwide spread of the so-called high-risk clones of multidrug-resistant
or extensively drug-resistant (MDR/XDR) Pseudomonas aeruginosa has become a public …

ESKAPE pathogens (Enterococcus faecium, Staphylococcus aureus, Klebsiella
pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter …

The polymyxin antibiotics colistin (polymyxin E) and polymyxin B became available in the
1950s and thus did not undergo contemporary drug development procedures. Their clinical …

Following their initial discovery in the 1940s, polymyxin antibiotics fell into disfavor due to
their potential clinical toxicity, especially nephrotoxicity. However, the dry antibiotic …

Abstract The Working Party makes more than 100 tabulated recommendations in
antimicrobial prescribing for the treatment of infections caused by multidrug-resistant (MDR) …

Antimicrobial resistance is now considered a major global challenge; compromising medical
advancements and our ability to treat infectious disease. Increased antimicrobial resistance …

Colistin is an antibiotic of last resort, but has poor efficacy and resistance is a growing
problem. Whilst it is well established that colistin disrupts the bacterial outer membrane (OM) …

It is important to realize that guidelines cannot always account for individual variation among
patients. They are not intended to supplant physician judgment with respect to particular …

It is important to realize that guidelines cannot always account for individual variation among
patients. They are not intended to supplant physician judgment with respect to particular …

Urinary tract infections (UTIs) caused by antibiotic-resistant Gram-negative bacteria are a
growing concern due to limited therapeutic options. Gram-negative bacteria, specifically …