Homologous recombination (HR) is a highly accurate DNA repair mechanism. Several HR
genes are established cancer susceptibility genes with clinically actionable pathogenic …

Homologous recombination (HR) is a vital process for repairing DNA double-strand breaks.
Germline variants in the HR pathway, comprising at least 10 genes, such as BRCA1 …

Background Population-based estimates of the risk of breast cancer associated with
germline pathogenic variants in cancer-predisposition genes are critically needed for risk …

PURPOSE To develop recommendations for management of patients with breast cancer
(BC) with germline mutations in BC susceptibility genes. METHODS The American Society …

PURPOSE Genetic testing for cancer risk has expanded rapidly. We examined clinical
genetic testing and results among population-based patients with breast and ovarian …

Purpose Despite the rapid uptake of multigene panel testing (MGPT) for hereditary cancer
predisposition, there is limited guidance surrounding indications for testing and genes to …

Pathogenic variants (PVs) in ATM are relatively common, but the scope and magnitude of
risk remains uncertain. This study aimed to estimate ATM PV cancer risks independent of …

Importance Since the discovery ofBRCA1andBRCA2, multiple high-and moderate-
penetrance genes have been reported as risk factors for hereditary breast cancer, ovarian …

Background A prior meta‐analysis found no association between BRCA1 mutation and
prostate cancer (PCa). Subsequent BRCA2 mutation studies have shown an association …

Breast and ovarian cancers are some of the most common tumors in females, and the
genetic predisposition is emerging as one of the key risk factors in the development of these …