In late 2020, after circulating for almost a year in the human population, severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) exhibited a major step change in its …

CRISPR screens are a powerful source of biological discovery, enabling the unbiased
interrogation of gene function in a wide range of applications and species. In pooled …

The unprecedented public health and economic impact of the COVID-19 pandemic caused
by infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been …

Since the first reports of a novel severe acute respiratory syndrome (SARS)-like coronavirus
in December 2019 in Wuhan, China, there has been intense interest in understanding how …

SARS-CoV-2 entry requires sequential cleavage of the spike glycoprotein at the S1/S2 and
the S2ʹ cleavage sites to mediate membrane fusion. SARS-CoV-2 has a polybasic insertion …

There is an urgent need for antiviral agents that treat severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) infection. We screened a library of 1900 clinically safe drugs …

Abstract The coronavirus disease 2019 (COVID-19) pandemic has claimed millions of lives
and caused a global economic crisis. No effective antiviral drugs are currently available to …

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes a range of
symptoms in infected individuals, from mild respiratory illness to acute respiratory distress …

Identification of host determinants of coronavirus infection informs mechanisms of viral
pathogenesis and can provide new drug targets. Here we demonstrate that mammalian …

SARS-CoV-2 is associated with broad tissue tropism, a characteristic often determined by
the availability of entry receptors on host cells. Here, we show that TMEM106B, a lysosomal …