[HTML][HTML] Role of glial cells in the generation of sex differences in neurodegenerative diseases and brain aging

JA Chowen, LM Garcia-Segura - Mechanisms of Ageing and Development, 2021 - Elsevier
Diseases and aging-associated alterations of the nervous system often show sex-specific
characteristics. Glial cells play a major role in the endogenous homeostatic response of …

Sex difference in biological change and mechanism of Alzheimer's disease: From macro-to micro-landscape

SS Cui, QW Jiang, SD Chen - Ageing Research Reviews, 2023 - Elsevier
Highlights•AD disproportionally affects women in the development, progression and clinical
presentation of AD.•Our review summarized sex differences in biological change of AD from …

High-Fat Diets in Animal Models of Alzheimer's Disease: How Can Eating Too Much Fat Increase Alzheimer's Disease Risk?

J Valentin-Escalera, M Leclerc… - Journal of Alzheimer's …, 2024 - content.iospress.com
High dietary intake of saturated fatty acids is a suspected risk factor for neurodegenerative
diseases, including Alzheimer's disease (AD). To decipher the causal link behind these …

Progressive excitability changes in the medial entorhinal cortex in the 3xTg mouse model of Alzheimer's disease pathology

L Chen, ZC Wick, LM Vetere, N Vaughan… - Journal of …, 2023 - Soc Neuroscience
Alzheimer's disease (AD) is a chronic neurodegenerative disorder characterized by memory
loss and progressive cognitive impairments. In mouse models of AD pathology, studies have …

Age related changes in muscle mass and force generation in the triple transgenic (3xTgAD) mouse model of Alzheimer's disease

H Xu, S Bhaskaran, KM Piekarz, R Ranjit… - Frontiers in Aging …, 2022 - frontiersin.org
Emerging evidence suggests that patients with Alzheimer's disease (AD) may show
accelerated sarcopenia phenotypes. To investigate whether pathological changes …

[HTML][HTML] Inhibition of PLK2 activity affects APP and tau pathology and improves synaptic content in a sex-dependent manner in a 3xTg mouse model of Alzheimer's …

L Martínez-Drudis, R Sheta, R Pellegrinato… - Neurobiology of …, 2022 - Elsevier
Converging lines of evidence suggest that abnormal accumulation of the kinase Polo-like
kinase 2 (PLK2) might play a role in the pathogenesis of Alzheimer's disease (AD), possibly …

Amyloid-β (1-42) peptide induces rapid NMDA receptor-dependent alterations at glutamatergic synapses in the entorhinal cortex

OJ Olajide, CA Chapman - Neurobiology of Aging, 2021 - Elsevier
The hippocampus and entorhinal cortex (EC) accumulate amyloid beta peptides (Aβ) that
promote neuropathology in Alzheimer's disease, but the early effects of Aβ on excitatory …

Pre-symptomatic synaptic dysfunction and longitudinal decay of hippocampal synaptic function in APPPS1 mouse model of Alzheimer's disease is sex-independent

S Sha, T Chaigneau, S Krantic - Brain Research Bulletin, 2023 - Elsevier
Alzheimer's disease (AD) is an incurable, age-related and progressive neurodegenerative
disease characterized by cognitive impairments. Deficits in synaptic plasticity were reported …

Early PSA-NCAM reduction in the dentate gyrus and impaired plasticity in the Alzheimer´ s disease 3xTg-mice model

JJ Rodríguez, E Gardenal, F Zallo, J Cabot… - Acta Histochemica, 2024 - Elsevier
Neurodegenerative diseases such as Alzheimer´ s (AD) and physiological ageing are
characterized by a decline in neurogenesis and in the polysialylated isoforms of neural cell …

Sex modifies effects of imaging and CSF biomarkers on cognitive and functional outcomes: a study of Alzheimer's disease

BN Lee, J Wang, MA Hall, D Kim, SD Stites, L Shen… - Neurobiology of …, 2024 - Elsevier
Alzheimer's disease (AD) is a neurodegenerative disorder characterized by memory and
functional impairments. Two of 3 patients with AD are biologically female; therefore, the …