[HTML][HTML] Role of glial cells in the generation of sex differences in neurodegenerative diseases and brain aging
JA Chowen, LM Garcia-Segura - Mechanisms of Ageing and Development, 2021 - Elsevier
Diseases and aging-associated alterations of the nervous system often show sex-specific
characteristics. Glial cells play a major role in the endogenous homeostatic response of …
characteristics. Glial cells play a major role in the endogenous homeostatic response of …
Sex difference in biological change and mechanism of Alzheimer's disease: From macro-to micro-landscape
SS Cui, QW Jiang, SD Chen - Ageing Research Reviews, 2023 - Elsevier
Highlights•AD disproportionally affects women in the development, progression and clinical
presentation of AD.•Our review summarized sex differences in biological change of AD from …
presentation of AD.•Our review summarized sex differences in biological change of AD from …
High-Fat Diets in Animal Models of Alzheimer's Disease: How Can Eating Too Much Fat Increase Alzheimer's Disease Risk?
J Valentin-Escalera, M Leclerc… - Journal of Alzheimer's …, 2024 - content.iospress.com
High dietary intake of saturated fatty acids is a suspected risk factor for neurodegenerative
diseases, including Alzheimer's disease (AD). To decipher the causal link behind these …
diseases, including Alzheimer's disease (AD). To decipher the causal link behind these …
Progressive excitability changes in the medial entorhinal cortex in the 3xTg mouse model of Alzheimer's disease pathology
Alzheimer's disease (AD) is a chronic neurodegenerative disorder characterized by memory
loss and progressive cognitive impairments. In mouse models of AD pathology, studies have …
loss and progressive cognitive impairments. In mouse models of AD pathology, studies have …
Age related changes in muscle mass and force generation in the triple transgenic (3xTgAD) mouse model of Alzheimer's disease
Emerging evidence suggests that patients with Alzheimer's disease (AD) may show
accelerated sarcopenia phenotypes. To investigate whether pathological changes …
accelerated sarcopenia phenotypes. To investigate whether pathological changes …
[HTML][HTML] Inhibition of PLK2 activity affects APP and tau pathology and improves synaptic content in a sex-dependent manner in a 3xTg mouse model of Alzheimer's …
L Martínez-Drudis, R Sheta, R Pellegrinato… - Neurobiology of …, 2022 - Elsevier
Converging lines of evidence suggest that abnormal accumulation of the kinase Polo-like
kinase 2 (PLK2) might play a role in the pathogenesis of Alzheimer's disease (AD), possibly …
kinase 2 (PLK2) might play a role in the pathogenesis of Alzheimer's disease (AD), possibly …
Amyloid-β (1-42) peptide induces rapid NMDA receptor-dependent alterations at glutamatergic synapses in the entorhinal cortex
OJ Olajide, CA Chapman - Neurobiology of Aging, 2021 - Elsevier
The hippocampus and entorhinal cortex (EC) accumulate amyloid beta peptides (Aβ) that
promote neuropathology in Alzheimer's disease, but the early effects of Aβ on excitatory …
promote neuropathology in Alzheimer's disease, but the early effects of Aβ on excitatory …
Pre-symptomatic synaptic dysfunction and longitudinal decay of hippocampal synaptic function in APPPS1 mouse model of Alzheimer's disease is sex-independent
S Sha, T Chaigneau, S Krantic - Brain Research Bulletin, 2023 - Elsevier
Alzheimer's disease (AD) is an incurable, age-related and progressive neurodegenerative
disease characterized by cognitive impairments. Deficits in synaptic plasticity were reported …
disease characterized by cognitive impairments. Deficits in synaptic plasticity were reported …
Early PSA-NCAM reduction in the dentate gyrus and impaired plasticity in the Alzheimer´ s disease 3xTg-mice model
JJ Rodríguez, E Gardenal, F Zallo, J Cabot… - Acta Histochemica, 2024 - Elsevier
Neurodegenerative diseases such as Alzheimer´ s (AD) and physiological ageing are
characterized by a decline in neurogenesis and in the polysialylated isoforms of neural cell …
characterized by a decline in neurogenesis and in the polysialylated isoforms of neural cell …
Sex modifies effects of imaging and CSF biomarkers on cognitive and functional outcomes: a study of Alzheimer's disease
Alzheimer's disease (AD) is a neurodegenerative disorder characterized by memory and
functional impairments. Two of 3 patients with AD are biologically female; therefore, the …
functional impairments. Two of 3 patients with AD are biologically female; therefore, the …